Literature DB >> 23608223

Going forward with genetics: recent technological advances and forward genetics in mice.

Eva Marie Y Moresco1, Xiaohong Li, Bruce Beutler.   

Abstract

Forward genetic analysis is an unbiased approach for identifying genes essential to defined biological phenomena. When applied to mice, it is one of the most powerful methods to facilitate understanding of the genetic basis of human biology and disease. The speed at which disease-causing mutations can be identified in mutagenized mice has been markedly increased by recent advances in DNA sequencing technology. Creating and analyzing mutant phenotypes may therefore become rate-limiting in forward genetic experimentation. We review the forward genetic approach and its future in the context of recent technological advances, in particular massively parallel DNA sequencing, induced pluripotent stem cells, and haploid embryonic stem cells.
Copyright © 2013 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.

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Year:  2013        PMID： 23608223      PMCID： PMC3644711          DOI： 10.1016/j.ajpath.2013.02.002

Source DB:  PubMed          Journal:  Am J Pathol        ISSN： 0002-9440            Impact factor:   4.307


  97 in total

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3.  A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity.

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Journal:  Nature       Date:  2005-05-26       Impact factor: 49.962

4.  Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene.

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Journal:  Science       Date:  1998-12-11       Impact factor: 47.728

5.  Hybrid selection of discrete genomic intervals on custom-designed microarrays for massively parallel sequencing.

Authors:  Emily Hodges; Michelle Rooks; Zhenyu Xuan; Arindam Bhattacharjee; D Benjamin Gordon; Leonardo Brizuela; W Richard McCombie; Gregory J Hannon
Journal:  Nat Protoc       Date:  2009-05-28       Impact factor: 13.491

6.  Positional cloning of the mouse obese gene and its human homologue.

Authors:  Y Zhang; R Proenca; M Maffei; M Barone; L Leopold; J M Friedman
Journal:  Nature       Date:  1994-12-01       Impact factor: 49.962

Review 7.  Appearances can be deceiving: phenotypes of knockout mice.

Authors:  Ivana Barbaric; Gaynor Miller; T Neil Dear
Journal:  Brief Funct Genomic Proteomic       Date:  2007-06-20

8.  Exome sequencing identifies a missense mutation in Isl1 associated with low penetrance otitis media in dearisch mice.

Authors:  Jennifer M Hilton; Morag A Lewis; M'hamed Grati; Neil Ingham; Selina Pearson; Roman A Laskowski; David J Adams; Karen P Steel
Journal:  Genome Biol       Date:  2011-09-21       Impact factor: 13.583

9.  Hybrid error correction and de novo assembly of single-molecule sequencing reads.

Authors:  Sergey Koren; Michael C Schatz; Brian P Walenz; Jeffrey Martin; Jason T Howard; Ganeshkumar Ganapathy; Zhong Wang; David A Rasko; W Richard McCombie; Erich D Jarvis
Journal:  Nat Biotechnol       Date:  2012-07-01       Impact factor: 54.908

10.  A mouse chromosome 4 balancer ENU-mutagenesis screen isolates eleven lethal lines.

Authors:  Melissa K Boles; Bonney M Wilkinson; Andrea Maxwell; Lihua Lai; Alea A Mills; Ichiko Nishijima; Andrew P Salinger; Ivan Moskowitz; Karen K Hirschi; Bin Liu; Allan Bradley; Monica J Justice
Journal:  BMC Genet       Date:  2009-03-06       Impact factor: 2.797
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  22 in total

Review 1.  Next-Generation Sequencing-Based Approaches for Mutation Mapping and Identification in Caenorhabditis elegans.

Authors:  Maria Doitsidou; Sophie Jarriault; Richard J Poole
Journal:  Genetics       Date:  2016-10       Impact factor: 4.562

2.  Sensitized mutagenesis screen in Factor V Leiden mice identifies thrombosis suppressor loci.

Authors:  Randal J Westrick; Kärt Tomberg; Amy E Siebert; Guojing Zhu; Mary E Winn; Sarah L Dobies; Sara L Manning; Marisa A Brake; Audrey C Cleuren; Linzi M Hobbs; Lena M Mishack; Alexander J Johnston; Emilee Kotnik; David R Siemieniak; Jishu Xu; Jun Z Li; Thomas L Saunders; David Ginsburg
Journal:  Proc Natl Acad Sci U S A       Date:  2017-08-21       Impact factor: 11.205

3.  Molecular variability elicits a tunable switch with discrete neuromodulatory response phenotypes.

Authors:  Warren D Anderson; Hirenkumar K Makadia; Rajanikanth Vadigepalli
Journal:  J Comput Neurosci       Date:  2015-12-01       Impact factor: 1.621

Review 4.  Tumour predisposition and cancer syndromes as models to study gene-environment interactions.

Authors:  Michele Carbone; Sarah T Arron; Bruce Beutler; Angela Bononi; Webster Cavenee; James E Cleaver; Carlo M Croce; Alan D'Andrea; William D Foulkes; Giovanni Gaudino; Joanna L Groden; Elizabeth P Henske; Ian D Hickson; Paul M Hwang; Richard D Kolodner; Tak W Mak; David Malkin; Raymond J Monnat; Flavia Novelli; Harvey I Pass; John H Petrini; Laura S Schmidt; Haining Yang
Journal:  Nat Rev Cancer       Date:  2020-05-29       Impact factor: 60.716

Review 5.  Consensus report of the 8 and 9th Weinman Symposia on Gene x Environment Interaction in carcinogenesis: novel opportunities for precision medicine.

Authors:  Michele Carbone; Ivano Amelio; El Bachir Affar; James Brugarolas; Lisa A Cannon-Albright; Lewis C Cantley; Webster K Cavenee; Zhijian Chen; Carlo M Croce; Alan D' Andrea; David Gandara; Carlotta Giorgi; Wei Jia; Qing Lan; Tak Wah Mak; James L Manley; Katsuhiko Mikoshiba; Jose N Onuchic; Harvey I Pass; Paolo Pinton; Carol Prives; Nathaniel Rothman; Said M Sebti; James Turkson; Xifeng Wu; Haining Yang; Herbert Yu; Gerry Melino
Journal:  Cell Death Differ       Date:  2018-10-15       Impact factor: 15.828

6.  CRISPR: a versatile tool for both forward and reverse genetics research.

Authors:  Channabasavaiah B Gurumurthy; M'hamed Grati; Masato Ohtsuka; Samantha L P Schilit; Rolen M Quadros; Xue Zhong Liu
Journal:  Hum Genet       Date:  2016-07-07       Impact factor: 4.132

Review 7.  Discovering antiviral restriction factors and pathways using genetic screens.

Authors:  Chloe E Jones; Wenfang S Tan; Finn Grey; David J Hughes
Journal:  J Gen Virol       Date:  2021-05       Impact factor: 3.891

8.  Germline Saturation Mutagenesis Induces Skeletal Phenotypes in Mice.

Authors:  Jonathan J Rios; Bruce Beutler; Kristin Denton; Jamie Russell; Julia Kozlitina; Carlos R Ferreira; Amy F Lewanda; Joshua E Mayfield; Eva Moresco; Sara Ludwig; Miao Tang; Xiaohong Li; Stephen Lyon; Anas Khanshour; Nandina Paria; Aysha Khalid; Yang Li; Xudong Xie; Jian Q Feng; Qian Xu; Yongbo Lu; Robert E Hammer; Carol A Wise
Journal:  J Bone Miner Res       Date:  2021-05-10       Impact factor: 6.390

9.  Simulation and estimation of gene number in a biological pathway using almost complete saturation mutagenesis screening of haploid mouse cells.

Authors:  Masahiro Tokunaga; Chikara Kokubu; Yusuke Maeda; Jun Sese; Kyoji Horie; Nakaba Sugimoto; Taroh Kinoshita; Kosuke Yusa; Junji Takeda
Journal:  BMC Genomics       Date:  2014-11-24       Impact factor: 3.969

Review 10.  Dissecting mammalian immunity through mutation.

Authors:  Owen M Siggs
Journal:  Immunol Cell Biol       Date:  2014-02-11       Impact factor: 5.126
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