Literature DB >> 18367323

Transforming growth factor beta suppresses beta-catenin/Wnt signaling and stimulates an adhesion response in human colon carcinoma cells in a Smad4/DPC4 independent manner.

Huijun Wang1, Shanthi Rajan, Guangming Liu, Subhas Chakrabarty.   

Abstract

Transforming growth factor beta (TGFbeta) suppresses the malignant phenotype of human colon carcinoma cells through diverse cellular pathways. Activation of beta-catenin/Wnt signal pathway underlies the malignant phenotype of human colon carcinomas. The Smad family of signal transducing, sequence-specific transcription activators are mediators of TGFbeta signaling. In this report, we showed that TGFbeta suppressed the beta-catenin/Wnt signal pathway in human colon carcinoma cells and stimulated an adhesion response in these cells in a Smad4/DPC4 independent manner. Smad/DCP4, however, was found to be linked to the growth-inhibitory action of TGFbeta.

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Year:  2008        PMID： 18367323      PMCID： PMC2474760          DOI： 10.1016/j.canlet.2008.01.039

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  25 in total

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Authors:  J Massagué
Journal:  Cell       Date:  1992-06-26       Impact factor: 41.582

2.  Tumor suppressor Smad4 is a transforming growth factor beta-inducible DNA binding protein.

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Journal:  Mol Cell Biol       Date:  1997-12       Impact factor: 4.272

3.  Induction of p21waf1 expression and growth inhibition by transforming growth factor beta involve the tumor suppressor gene DPC4 in human pancreatic adenocarcinoma cells.

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Journal:  Cancer Res       Date:  1997-09-15       Impact factor: 12.701

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Authors:  G Lagna; A Hata; A Hemmati-Brivanlou; J Massagué
Journal:  Nature       Date:  1996-10-31       Impact factor: 49.962

5.  Modulation of differentiation and proliferation in human colon carcinoma cells by transforming growth factor beta 1 and beta 2.

Authors:  S Chakrabarty; D Fan; J Varani
Journal:  Int J Cancer       Date:  1990-09-15       Impact factor: 7.396

Review 6.  The type II transforming growth factor-beta receptor as a tumor-suppressor gene.

Authors:  M G Brattain; S D Markowitz; J K Willson
Journal:  Curr Opin Oncol       Date:  1996-01       Impact factor: 3.645

7.  Diverse cellular responses elicited from human colon carcinoma cells by transforming growth factor-beta.

Authors:  S Chakrabarty; Y Jan; M G Brattain; A Tobon; J Varani
Journal:  Cancer Res       Date:  1989-04-15       Impact factor: 12.701

8.  The tumor suppressor Smad4/DPC 4 as a central mediator of Smad function.

Authors:  Y Zhang; T Musci; R Derynck
Journal:  Curr Biol       Date:  1997-04-01       Impact factor: 10.834

9.  Regulation of fibronectin and laminin receptor expression, fibronectin and laminin secretion in human colon cancer cells by transforming growth factor-beta 1.

Authors:  S Huang; S Chakrabarty
Journal:  Int J Cancer       Date:  1994-06-01       Impact factor: 7.396

10.  Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability.

Authors:  S Markowitz; J Wang; L Myeroff; R Parsons; L Sun; J Lutterbaugh; R S Fan; E Zborowska; K W Kinzler; B Vogelstein
Journal:  Science       Date:  1995-06-02       Impact factor: 47.728
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  7 in total

1.  Moderate oxidative stress promotes epithelial-mesenchymal transition in the lens epithelial cells via the TGF-β/Smad and Wnt/β-catenin pathways.

Authors:  Xi Chen; Hong Yan; Ying Chen; Guo Li; Yue Bin; Xiyuan Zhou
Journal:  Mol Cell Biochem       Date:  2021-01-08       Impact factor: 3.396

2.  Comparison of beta-catenin with TGF-beta1, HIF-1alpha and patients' disease-free survival in human colorectal cancer.

Authors:  Andrzej Wincewicz; Mariusz Koda; Stanislaw Sulkowski; Luiza Kanczuga-Koda; Mariola Sulkowska
Journal:  Pathol Oncol Res       Date:  2009-11-08       Impact factor: 3.201

3.  Switch of transforming growth factor beta function from tumor suppression to stimulation in adenomatous polyposis coli (APC) knocked-down human colon carcinoma cells.

Authors:  Hongmei Wang; Moltira Promkan; Guangming Liu; Subhas Chakrabarty
Journal:  Cancer Lett       Date:  2008-09-06       Impact factor: 8.679

4.  Silencing Smad4 attenuates sensitivity of colorectal cancer cells to cetuximab by promoting epithelial‑mesenchymal transition.

Authors:  Zhenlv Lin; Lin Zhang; Junfeng Zhou; Jiantao Zheng
Journal:  Mol Med Rep       Date:  2019-08-21       Impact factor: 2.952

5.  SMAD4 alteration associates with invasive-front pathological markers and poor prognosis in colorectal cancer.

Authors:  Hidehito Oyanagi; Yoshifumi Shimada; Masayuki Nagahashi; Hiroshi Ichikawa; Yosuke Tajima; Kaoru Abe; Masato Nakano; Hitoshi Kameyama; Yasumasa Takii; Takashi Kawasaki; Kei-Ichi Homma; Yiwei Ling; Shujiro Okuda; Kazuaki Takabe; Toshifumi Wakai
Journal:  Histopathology       Date:  2019-04-01       Impact factor: 5.087

Review 6.  TGF-β - an excellent servant but a bad master.

Authors:  Lenka Kubiczkova; Lenka Sedlarikova; Roman Hajek; Sabina Sevcikova
Journal:  J Transl Med       Date:  2012-09-03       Impact factor: 5.531

7.  Loss of TGF-beta or Wnt5a results in an increase in Wnt/beta-catenin activity and redirects mammary tumour phenotype.

Authors:  Kevin Roarty; Sarah E Baxley; Michael R Crowley; Andra R Frost; Rosa Serra
Journal:  Breast Cancer Res       Date:  2009-04-03       Impact factor: 6.466
  7 in total

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