Literature DB >> 18365660

Histone deacetylases.

David Horn1.   

Abstract

Deacetylation of histones is required for gene regulation and cell cycle progression and the mediators, the histone deacetylases, are being vigorously pursued as drug targets for cancer chemotherapy. The deacetylases are also potential drug targets against infectious diseases and genome sequencing revealed proteins of this class in each of three kinetoplastid parasites. These enzymes are now being characterised and assessed for chemotherapeutic potential.

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Year:  2008        PMID： 18365660     DOI： 10.1007/978-0-387-77570-8_7

Source DB:  PubMed          Journal:  Adv Exp Med Biol        ISSN： 0065-2598            Impact factor:   2.622


  7 in total

Review 1.  Chemical probes in plant epigenetics studies.

Authors:  Huiming Zhang; Bangshing Wang; Cheng-Guo Duan; Jian-Kang Zhu
Journal:  Plant Signal Behav       Date:  2013-06-27

Review 2.  Bromodomains in Protozoan Parasites: Evolution, Function, and Opportunities for Drug Development.

Authors:  Victoria Jeffers; Chunlin Yang; Sherri Huang; William J Sullivan
Journal:  Microbiol Mol Biol Rev       Date:  2017-01-11       Impact factor: 11.056

3.  Target Identification and Intervention Strategies against Kinetoplastid Protozoan Parasites.

Authors:  Hemanta K Majumder; Wanderley de Souza; Kwang Poo Chang
Journal:  Mol Biol Int       Date:  2011-08-09

4.  Chemistry, antiproliferative properties, tumor selectivity, and molecular mechanisms of novel gold(III) compounds for cancer treatment: a systematic study.

Authors:  Angela Casini; Gerhard Kelter; Chiara Gabbiani; Maria Agostina Cinellu; Giovanni Minghetti; Dolores Fregona; Heinz-Herbert Fiebig; Luigi Messori
Journal:  J Biol Inorg Chem       Date:  2009-06-20       Impact factor: 3.358

Review 5.  Antiparasitic chemotherapy: from genomes to mechanisms.

Authors:  David Horn; Manoj T Duraisingh
Journal:  Annu Rev Pharmacol Toxicol       Date:  2013-09-11       Impact factor: 13.820

6.  Histone deacetylases play distinct roles in telomeric VSG expression site silencing in African trypanosomes.

Authors:  Qiao-Ping Wang; Taemi Kawahara; David Horn
Journal:  Mol Microbiol       Date:  2010-09       Impact factor: 3.501

7.  Targeting Lysine Deacetylases (KDACs) in Parasites.

Authors:  Qi Wang; Bruce A Rosa; Bakela Nare; Kerrie Powell; Sergio Valente; Dante Rotili; Antonello Mai; Garland R Marshall; Makedonka Mitreva
Journal:  PLoS Negl Trop Dis       Date:  2015-09-24
  7 in total

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