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Literature DB >> 18365657

Selective lead compounds against kinetoplastid tubulin.

Abstract

Kinetoplastid parasites are responsible for the potentially fatal diseases leishmaniasis, African sleeping sickness and Chagas disease. The current treatments for these diseases are far from ideal and new compounds are needed as antiparasitic drug candidates. Tubulin is the accepted target for treatments against cancer and helminths, suggesting that kinetoplastid tubulin is also a suitable target for antiprotozoal compounds. Selective lead compounds against kinetoplastid tubulin have been identified that could represent a starting point for the development of new drug candidates against these parasites.

Entities: Disease

Mesh：

Substances：

Year: 2008 PMID： 18365657 DOI： 10.1007/978-0-387-77570-8_4

Source DB: PubMed Journal: Adv Exp Med Biol ISSN： 0065-2598 Impact factor: 2.622

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Cited

6 in total

1. α-Tubulin mutations alter oryzalin affinity and microtubule assembly properties to confer dinitroaniline resistance.

Authors: Sally Lyons-Abbott; Dan L Sackett; Dorota Wloga; Jacek Gaertig; Rachel E Morgan; Karl A Werbovetz; Naomi S Morrissette
Journal: Eukaryot Cell Date: 2010-09-24

Review 2. Recent developments in drug discovery for leishmaniasis and human African trypanosomiasis.

Authors: Advait S Nagle; Shilpi Khare; Arun Babu Kumar; Frantisek Supek; Andriy Buchynskyy; Casey J N Mathison; Naveen Kumar Chennamaneni; Nagendar Pendem; Frederick S Buckner; Michael H Gelb; Valentina Molteni
Journal: Chem Rev Date: 2014-11-03 Impact factor: 60.622

6. Comparative analyses of the β-tubulin gene and molecular modeling reveal molecular insight into the colchicine resistance in kinetoplastids organisms.

Authors: Luis Luis; María Luisa Serrano; Mariana Hidalgo; Alexis Mendoza-León
Journal: Biomed Res Int Date: 2013-09-08 Impact factor: 3.411

6 in total

Selective lead compounds against kinetoplastid tubulin.

1. α-Tubulin mutations alter oryzalin affinity and microtubule assembly properties to confer dinitroaniline resistance.

Review 2. Recent developments in drug discovery for leishmaniasis and human African trypanosomiasis.

Review 3. Drug target identification in protozoan parasites.

Review 4. The Dialogue of the Host-Parasite Relationship: Leishmania spp. and Trypanosoma cruzi Infection.

5. Systematic Analysis of Clemastine, a Candidate Apicomplexan Parasite-Selective Tubulin-Targeting Agent.

6. Comparative analyses of the β-tubulin gene and molecular modeling reveal molecular insight into the colchicine resistance in kinetoplastids organisms.