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Literature DB >> 18362882

Evolutionary plasticity of genetic interaction networks.

Julia Tischler¹, Ben Lehner, Andrew G Fraser.

Abstract

Non-additive genetic interactions contribute to many genetic disorders, but they are extremely difficult to predict. Here we show that genetic interactions identified in yeast, unlike gene functions or protein interactions, are not highly conserved in animals. Genetic interactions are therefore unlikely to represent simple redundancy between genes or pathways, and genetic interactions from yeast do not directly predict genetic interactions in higher eukaryotes, including humans.

Entities: Disease Species

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Year: 2008 PMID： 18362882 DOI： 10.1038/ng.114

Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330

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Cited

67 in total

1. Predicting genetic modifier loci using functional gene networks.

Authors: Insuk Lee; Ben Lehner; Tanya Vavouri; Junha Shin; Andrew G Fraser; Edward M Marcotte
Journal: Genome Res Date: 2010-06-09 Impact factor: 9.043

2. A genome-wide map of human genetic interactions inferred from radiation hybrid genotypes.

Authors: Andy Lin; Richard T Wang; Sangtae Ahn; Christopher C Park; Desmond J Smith
Journal: Genome Res Date: 2010-05-27 Impact factor: 9.043

3. Traversing a wormhole to combat Parkinson's disease.

Authors: Guy A Caldwell; Kim A Caldwell
Journal: Dis Model Mech Date: 2008 Jul-Aug Impact factor: 5.758

4. Genomic consequences of background effects on scalloped mutant expressivity in the wing of Drosophila melanogaster.

Authors: Ian Dworkin; Erin Kennerly; David Tack; Jennifer Hutchinson; Julie Brown; James Mahaffey; Greg Gibson
Journal: Genetics Date: 2008-12-08 Impact factor: 4.562

5. Conserved and differential gene interactions in dynamical biological systems.

Authors: Zhengyu Ouyang; Mingzhou Song; Robert Güth; Thomas J Ha; Matt Larouche; Dan Goldowitz
Journal: Bioinformatics Date: 2011-08-11 Impact factor: 6.937

6. Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast.

Authors: Assen Roguev; Sourav Bandyopadhyay; Martin Zofall; Ke Zhang; Tamas Fischer; Sean R Collins; Hongjing Qu; Michael Shales; Han-Oh Park; Jacqueline Hayles; Kwang-Lae Hoe; Dong-Uk Kim; Trey Ideker; Shiv I Grewal; Jonathan S Weissman; Nevan J Krogan
Journal: Science Date: 2008-09-25 Impact factor: 47.728

Evolutionary plasticity of genetic interaction networks.

1. Predicting genetic modifier loci using functional gene networks.

2. A genome-wide map of human genetic interactions inferred from radiation hybrid genotypes.

3. Traversing a wormhole to combat Parkinson's disease.

4. Genomic consequences of background effects on scalloped mutant expressivity in the wing of Drosophila melanogaster.

5. Conserved and differential gene interactions in dynamical biological systems.

6. Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast.

Review 7. Epistasis--the essential role of gene interactions in the structure and evolution of genetic systems.

8. The fate of gene duplicates in the genomes of fungal pathogens.

Review 9. Drug interactions and the evolution of antibiotic resistance.

10. Co-evolutionary networks of genes and cellular processes across fungal species.