Literature DB >> 18362196

Interactions of DB75, a novel antimalarial agent, with other antimalarial drugs in vitro.

Anne E Purfield1, Richard R Tidwell, Steven R Meshnick.   

Abstract

Pafuramidine is a novel orally active antimalarial. To identify a combination partner, we measured the in vitro antimalarial activities of the active metabolite, DB75, with amodiaquine, artemisinin, atovaquone, azithromycin, chloroquine, clindamycin, mefloquine, piperaquine, pyronaridine, tafenoquine, and tetracycline. None of the drugs tested demonstrated antagonistic or synergistic activity in combination with pafuramidine.

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Year:  2008        PMID： 18362196      PMCID： PMC2415804          DOI： 10.1128/AAC.01536-07

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  10 in total

1.  Development of pentamidine analogues as new agents for the treatment of Pneumocystis carinii pneumonia.

Authors:  R R Tidwell; S K Jones; J D Geratz; K A Ohemeng; C A Bell; B J Berger; J E Hall
Journal:  Ann N Y Acad Sci       Date:  1990       Impact factor: 5.691

2.  Efficacy of DB289 in Thai patients with Plasmodium vivax or acute, uncomplicated Plasmodium falciparum infections.

Authors:  Patrick Yeramian; Steven R Meshnick; Srivicha Krudsood; Kobsiri Chalermrut; Udomsak Silachamroon; Noppadon Tangpukdee; James Allen; Reto Brun; Jesse J Kwiek; Richard Tidwell; Sornchai Looareesuwan
Journal:  J Infect Dis       Date:  2005-06-07       Impact factor: 5.226

3.  Diamidine compounds: selective uptake and targeting in Plasmodium falciparum.

Authors:  A M Stead; P G Bray; I G Edwards; H P DeKoning; B C Elford; P A Stocks; S A Ward
Journal:  Mol Pharmacol       Date:  2001-05       Impact factor: 4.436

4.  Interactions of atovaquone with other antimalarial drugs against Plasmodium falciparum in vitro.

Authors:  C J Canfield; M Pudney; W E Gutteridge
Journal:  Exp Parasitol       Date:  1995-05       Impact factor: 2.011

5.  A method for testing for synergy with any number of agents.

Authors:  M C Berenbaum
Journal:  J Infect Dis       Date:  1978-02       Impact factor: 5.226

6.  Enhanced permeability of the antimicrobial agent 2,5-bis(4-amidinophenyl)furan across Caco-2 cell monolayers via its methylamidoidme prodrug.

Authors:  Liao Zhou; Kiho Lee; Dhiren R Thakker; David W Boykin; Richard R Tidwell; James E Hall
Journal:  Pharm Res       Date:  2002-11       Impact factor: 4.200

7.  Antileishmanial activities of several classes of aromatic dications.

Authors:  James J Brendle; Abram Outlaw; Arvind Kumar; David W Boykin; Donald A Patrick; Richard R Tidwell; Karl A Werbovetz
Journal:  Antimicrob Agents Chemother       Date:  2002-03       Impact factor: 5.191

8.  Clindamycin activity against chloroquine-resistant Plasmodium falciparum.

Authors:  L S Seaberg; A R Parquette; I Y Gluzman; G W Phillips; T F Brodasky; D J Krogstad
Journal:  J Infect Dis       Date:  1984-12       Impact factor: 5.226

9.  Metabolites of an orally active antimicrobial prodrug, 2,5-bis(4-amidinophenyl)furan-bis-O-methylamidoxime, identified by liquid chromatography/tandem mass spectrometry.

Authors:  Lian Zhou; Dhiren R Thakker; Robert D Voyksner; Mariappan Anbazhagan; David W Boykin; James E Hall; Richard R Tidwell
Journal:  J Mass Spectrom       Date:  2004-04       Impact factor: 1.982

10.  Quantitative assessment of antimalarial activity in vitro by a semiautomated microdilution technique.

Authors:  R E Desjardins; C J Canfield; J D Haynes; J D Chulay
Journal:  Antimicrob Agents Chemother       Date:  1979-12       Impact factor: 5.191
  10 in total

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