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Literature DB >> 1836162

Human colostrum contains an activity that inhibits the production of IL-2.

J W Hooton¹, H F Pabst, D W Spady, V Paetkau.

Abstract

The effect of human colostrum on T cell immune function was investigated. Colostrum inhibited the proliferation of human T cells activated by allogeneic, concanavalin A (Con A) or phytohaemagglutinin (PHA) stimulation. Colostrum also inhibited the production of IL-2 by Con A-activated human peripheral blood T cells and by Con A-activated Jurkat cells, a human T lymphoma line. Similarly, human colostrum inhibited the production of IL-2 by EL4 cells, a murine thymoma line, when stimulated with phorbol myristate acetate. The inhibitory activity was not cytotoxic and could not be neutralized by antibody to transforming human growth factor beta.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 1991 PMID： 1836162 PMCID： PMC1554205 DOI： 10.1111/j.1365-2249.1991.tb02963.x

Source DB: PubMed Journal: Clin Exp Immunol ISSN： 0009-9104 Impact factor: 4.330

19 in total

1. Effect of breast-feeding on immune response to BCG vaccination.

Authors: H F Pabst; J Godel; M Grace; H Cho; D W Spady
Journal: Lancet Date: 1989-02-11 Impact factor: 79.321

2. In vivo distribution of human milk leucocytes after ingestion by newborn baboons.

Authors: L Jain; D Vidyasagar; M Xanthou; V Ghai; S Shimada; M Blend
Journal: Arch Dis Child Date: 1989-07 Impact factor: 3.791

3. Comparison of the immunosuppressive properties of milk growth factor and transforming growth factors beta 1 and beta 2.

Authors: M Stoeck; C Ruegg; S Miescher; S Carrel; D Cox; V Von Fliedner; S Alkan
Journal: J Immunol Date: 1989-11-15 Impact factor: 5.422

4. Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: homology to Epstein-Barr virus open reading frame BCRFI.

Authors: P Vieira; R de Waal-Malefyt; M N Dang; K E Johnson; R Kastelein; D F Fiorentino; J E deVries; M G Roncarolo; T R Mosmann; K W Moore
Journal: Proc Natl Acad Sci U S A Date: 1991-02-15 Impact factor: 11.205

5. Intestinal absorption of maternal leucocytes by newborn lambs.

Authors: K L Schnorr; L D Pearson
Journal: J Reprod Immunol Date: 1984-08 Impact factor: 4.054

6. Interaction of interleukin 2 with cells: quantitative analysis of effects.

Authors: J W Hooton; C Gibbs; V Paetkau
Journal: J Immunol Date: 1985-10 Impact factor: 5.422

7. Estimation by limiting dilution analysis of human IL 2-secreting T cells: detection of IL 2 produced by single lymphokine-secreting T cells.

Authors: H Vie; R A Miller
Journal: J Immunol Date: 1986-05-01 Impact factor: 5.422

Human colostrum contains an activity that inhibits the production of IL-2.

1. Effect of breast-feeding on immune response to BCG vaccination.

2. In vivo distribution of human milk leucocytes after ingestion by newborn baboons.

3. Comparison of the immunosuppressive properties of milk growth factor and transforming growth factors beta 1 and beta 2.

4. Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: homology to Epstein-Barr virus open reading frame BCRFI.

5. Intestinal absorption of maternal leucocytes by newborn lambs.

6. Interaction of interleukin 2 with cells: quantitative analysis of effects.

7. Estimation by limiting dilution analysis of human IL 2-secreting T cells: detection of IL 2 produced by single lymphokine-secreting T cells.

8. A colostral protein that induces the growth and differentiation of resting B lymphocytes.

9. Effect of breast-feeding on antibody response to conjugate vaccine.

10. In vitro studies on the T-lymphocyte population of human milk.

Review 1. Cytokines in human milk: properties and potential effects upon the mammary gland and the neonate.

2. Effect of human colostrum on interleukin-2 production and natural killer cell activity.