Literature DB >> 18356813

Using gene transfer to circumvent off-target effects.

C P Miller1, C A Blau.   

Abstract

Many recombinant growth factors have failed in clinical trials due to off-target effects. We describe a method for circumventing off-target effects that involves equipping cells with a conditionally active signaling protein that can be specifically activated by an exogenously administered synthetic ligand. We believe that this approach will have many applications in gene and cell therapy.

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Year:  2008        PMID： 18356813     DOI： 10.1038/gt.2008.43

Source DB:  PubMed          Journal:  Gene Ther        ISSN： 0969-7128            Impact factor:   5.250


  5 in total

1.  Long-term regulation of genetically modified primary hematopoietic cells in dogs.

Authors:  Kiyoshi Okazuka; Brian C Beard; David W Emery; Kerstin Schwarzwaelder; Michele R Spector; George E Sale; Christof von Kalle; Beverly Torok-Storb; Hans-Peter Kiem; C Anthony Blau
Journal:  Mol Ther       Date:  2011-02-15       Impact factor: 11.454

2.  A hyperactive Mpl-based cell growth switch drives macrophage-associated erythropoiesis through an erythroid-megakaryocytic precursor.

Authors:  Eyayu Belay; Chris P Miller; Amanda N Kortum; Beverly Torok-Storb; C Anthony Blau; David W Emery
Journal:  Blood       Date:  2014-10-24       Impact factor: 22.113

3.  A composite MyD88/CD40 switch synergistically activates mouse and human dendritic cells for enhanced antitumor efficacy.

Authors:  Priyadharshini Narayanan; Natalia Lapteva; Mamatha Seethammagari; Jonathan M Levitt; Kevin M Slawin; David M Spencer
Journal:  J Clin Invest       Date:  2011-03-07       Impact factor: 14.808

4.  Catch and Release: Photocleavable Cationic Diblock Copolymers as a Potential Platform for Nucleic Acid Delivery.

Authors:  Matthew D Green; Abbygail A Foster; Chad T Greco; Raghunath Roy; Rachel M Lehr; Thomas H Epps; Millicent O Sullivan
Journal:  Polym Chem       Date:  2014-06       Impact factor: 5.582

5.  In vivo regulation of erythropoiesis by chemically inducible dimerization of the erythropoietin receptor intracellular domain.

Authors:  Norio Suzuki; Harumi Y Mukai; Masayuki Yamamoto
Journal:  PLoS One       Date:  2015-03-19       Impact factor: 3.240
  5 in total

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