OBJECTIVE: In participants of the Diabetes Prevention Program (DPP) randomized to intensive lifestyle modification (ILS), meeting ILS goals strongly correlated with prevention of diabetes in the group as a whole. Men met significantly more ILS goals than women but had a similar incidence of diabetes. Therefore, we explored sex differences in risk factors for diabetes and the effect of ILS on risk factors. RESEARCH DESIGN AND METHODS: Baseline risk factors for diabetes and percent change in risk factors over the first year in men versus women were compared using Wilcoxon's rank-sum tests. RESULTS: At baseline, men were older and had a larger waist circumference; higher fasting plasma glucose concentration, caloric intake, and blood pressure; and lower HDL cholesterol and corrected insulin response than women, who were less physically active and had a higher BMI (P < 0.01 for all comparisons). Over the first year of the DPP, no sex difference in risk factors for diabetes was observed for those who lost <3% body weight. Weight loss of 3-7% body weight yielded greater decreases in 2-h glucose (P < 0.01), insulin concentration (P < 0.04), and insulin resistance (P < 0.03) in men than in women. Weight loss of >7% body weight resulted in greater decreases in 2-h glucose (P < 0.01), triglyceride level (P < 0.01), and A1C (P < 0.03) in men than in women. CONCLUSIONS:Weight loss >3% body weight yielded greater reduction in risk factors for diabetes in men than in women. Despite the more favorable effects of ILS in men, baseline risk factors were more numerous in men and likely obscured any sex difference in incident diabetes.
RCT Entities:
OBJECTIVE: In participants of the Diabetes Prevention Program (DPP) randomized to intensive lifestyle modification (ILS), meeting ILS goals strongly correlated with prevention of diabetes in the group as a whole. Men met significantly more ILS goals than women but had a similar incidence of diabetes. Therefore, we explored sex differences in risk factors for diabetes and the effect of ILS on risk factors. RESEARCH DESIGN AND METHODS: Baseline risk factors for diabetes and percent change in risk factors over the first year in men versus women were compared using Wilcoxon's rank-sum tests. RESULTS: At baseline, men were older and had a larger waist circumference; higher fasting plasma glucose concentration, caloric intake, and blood pressure; and lower HDL cholesterol and corrected insulin response than women, who were less physically active and had a higher BMI (P < 0.01 for all comparisons). Over the first year of the DPP, no sex difference in risk factors for diabetes was observed for those who lost <3% body weight. Weight loss of 3-7% body weight yielded greater decreases in 2-h glucose (P < 0.01), insulin concentration (P < 0.04), and insulin resistance (P < 0.03) in men than in women. Weight loss of >7% body weight resulted in greater decreases in 2-h glucose (P < 0.01), triglyceride level (P < 0.01), and A1C (P < 0.03) in men than in women. CONCLUSIONS: Weight loss >3% body weight yielded greater reduction in risk factors for diabetes in men than in women. Despite the more favorable effects of ILS in men, baseline risk factors were more numerous in men and likely obscured any sex difference in incident diabetes.
Authors: Richard F Hamman; Rena R Wing; Sharon L Edelstein; John M Lachin; George A Bray; Linda Delahanty; Mary Hoskin; Andrea M Kriska; Elizabeth J Mayer-Davis; Xavier Pi-Sunyer; Judith Regensteiner; Beth Venditti; Judith Wylie-Rosett Journal: Diabetes Care Date: 2006-09 Impact factor: 19.112
Authors: H C Gerstein; S Yusuf; J Bosch; J Pogue; P Sheridan; N Dinccag; M Hanefeld; B Hoogwerf; M Laakso; V Mohan; J Shaw; B Zinman; R R Holman Journal: Lancet Date: 2006-09-23 Impact factor: 79.321
Authors: J Tuomilehto; J Lindström; J G Eriksson; T T Valle; H Hämäläinen; P Ilanne-Parikka; S Keinänen-Kiukaanniemi; M Laakso; A Louheranta; M Rastas; V Salminen; M Uusitupa Journal: N Engl J Med Date: 2001-05-03 Impact factor: 91.245
Authors: S L Edelstein; W C Knowler; R P Bain; R Andres; E L Barrett-Connor; G K Dowse; S M Haffner; D J Pettitt; J D Sorkin; D C Muller; V R Collins; R F Hamman Journal: Diabetes Date: 1997-04 Impact factor: 9.461
Authors: Edward W Gregg; Qiuping Gu; Yiling J Cheng; K M Venkat Narayan; Catherine C Cowie Journal: Ann Intern Med Date: 2007-06-18 Impact factor: 25.391
Authors: Ira S Ockene; Trinidad L Tellez; Milagros C Rosal; George W Reed; John Mordes; Philip A Merriam; Barbara C Olendzki; Garry Handelman; Robert Nicolosi; Yunsheng Ma Journal: Am J Public Health Date: 2011-12-15 Impact factor: 9.308
Authors: Robin Shoemaker; Frederique Yiannikouris; Sean Thatcher; Lisa Cassis Journal: Am J Physiol Endocrinol Metab Date: 2015-08-04 Impact factor: 4.310
Authors: David J Decewicz; David M Neatrour; Amy Burke; Mary Jane Haberkorn; Heather L Patney; Marina N Vernalis; Darrell L Ellsworth Journal: Lipids Health Dis Date: 2009-06-29 Impact factor: 3.876
Authors: Timo Saaristo; Leena Moilanen; Eeva Korpi-Hyövälti; Mauno Vanhala; Juha Saltevo; Leo Niskanen; Jari Jokelainen; Markku Peltonen; Heikki Oksa; Jaakko Tuomilehto; Matti Uusitupa; Sirkka Keinänen-Kiukaanniemi Journal: Diabetes Care Date: 2010-07-27 Impact factor: 19.112