OBJECTIVE: Evaluation of serum and synovial fluid OPG and sRANKL in 37 patients with primary knee osteoarthritis. DESIGN AND METHOD: OPG and sRANKL were measured using ELISA. RESULTS: OPG, sRANKL and sRANKL/OPG were increased in osteoarthritis patients' serum. Synovial OPG was higher than serum OPG, while sRANKL/OPG was higher in the serum; both correlated with disease severity. DISCUSSION: RANKL/OPG pathway is implicated in the pathogenesis of knee osteoarthritis being a suitable target for therapeutic intervention.
OBJECTIVE: Evaluation of serum and synovial fluid OPG and sRANKL in 37 patients with primary knee osteoarthritis. DESIGN AND METHOD:OPG and sRANKL were measured using ELISA. RESULTS:OPG, sRANKL and sRANKL/OPG were increased in osteoarthritispatients' serum. Synovial OPG was higher than serum OPG, while sRANKL/OPG was higher in the serum; both correlated with disease severity. DISCUSSION: RANKL/OPG pathway is implicated in the pathogenesis of knee osteoarthritis being a suitable target for therapeutic intervention.
Authors: Weiqiang Chen; Suan-Sin Foo; Adam Taylor; Aleksei Lulla; Andres Merits; Linda Hueston; Mark R Forwood; Nicole C Walsh; Natalie A Sims; Lara J Herrero; Suresh Mahalingam Journal: J Virol Date: 2014-10-22 Impact factor: 5.103
Authors: Miriam Bellido; Laura Lugo; Jorge A Roman-Blas; Santos Castañeda; Jose R Caeiro; Sonia Dapia; Emilio Calvo; Raquel Largo; Gabriel Herrero-Beaumont Journal: Arthritis Res Ther Date: 2010-08-02 Impact factor: 5.156