Literature DB >> 18355032

Antiepileptic ceramides from the Red Sea sponge Negombata corticata.

Safwat A Ahmed1, Sherief I Khalifa, Mark T Hamann.   

Abstract

A new antiepileptic ceramide mixture 1 was isolated from the Red Sea sponge Negombata corticata. The structures of the metabolites were determined by extensive spectroscopic analysis. The anticonvulsant activity of 1 was measured in vivo using the pentylenetetrazole-induced seizure model. This finding has important implications for biological studies with this class of compounds.

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Year:  2008        PMID： 18355032      PMCID： PMC4907267          DOI： 10.1021/np0703287

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  13 in total

1.  New lipids from the tunicate Cystodytes cf. dellechiajei, as PLA2 inhibitors.

Authors:  A Loukaci; V Bultel-Poncé; A Longeon; M Guyot
Journal:  J Nat Prod       Date:  2000-06       Impact factor: 4.050

2.  Analysis of sphingomyelin and ceramide levels and the enzymes regulating their metabolism in response to cell stress.

Authors:  R T Dobrowsky; R N Kolesnick
Journal:  Methods Cell Biol       Date:  2001       Impact factor: 1.441

3.  New sphingosines from the marine sponge Grayella cyatophora.

Authors:  Michèle Meyer; Michèle Guyot
Journal:  J Nat Prod       Date:  2002-11       Impact factor: 4.050

4.  New ceramide from marine sponge Haliclona koremella and related compounds as antifouling substances against macroalgae.

Authors:  T Hattori; K Adachi; Y Shizuri
Journal:  J Nat Prod       Date:  1998-06-26       Impact factor: 4.050

5.  Modification of seizure activity by electrical stimulation. II. Motor seizure.

Authors:  R J Racine
Journal:  Electroencephalogr Clin Neurophysiol       Date:  1972-03

6.  New sphingolipids from marine sponge Iotrochota baculifera.

Authors:  Pendyala Muralidhar; Nallamothu Krishna; Muthyala Muralikrishna Kumar; Chaganty Bheemasankara Rao; Desaraju Venkata Rao
Journal:  Chem Pharm Bull (Tokyo)       Date:  2003-10       Impact factor: 1.645

7.  Latrunculin with a highly oxidized thiazolidinone ring: structure assignment and actin docking.

Authors:  Safwat A Ahmed; Srinivas Odde; Pankaj R Daga; John J Bowling; Mostafa K Mesbah; Diaa T Youssef; Sherief I Khalifa; Robert J Doerksen; Mark T Hamann
Journal:  Org Lett       Date:  2007-10-12       Impact factor: 6.005

8.  Effects of anticonvulsive drugs on pentylenetetrazol kindling and long-term potentiation in freely moving rats.

Authors:  M Krug; A Becker; G Grecksch; A Pfeiffer; R Matthies; M Wagner
Journal:  Eur J Pharmacol       Date:  1998-09-04       Impact factor: 4.432

Review 9.  Sphingolipid functions in Saccharomyces cerevisiae: comparison to mammals.

Authors:  R C Dickson
Journal:  Annu Rev Biochem       Date:  1998       Impact factor: 23.643

10.  A new dimension to the biosynthetic products isolated from the sponge Negombata magnifica.

Authors:  Boaz Vilozny; Taro Amagata; Susan L Mooberry; Phillip Crews
Journal:  J Nat Prod       Date:  2004-06       Impact factor: 4.050
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  4 in total

1.  Anticonvulsant and analgesic activities of crude extract and its fractions of the defensive secretion from the Mediterranean sponge, Spongia officinalis.

Authors:  Afef Dellai; Hedi Ben Mansour; Audrey Clary-Laroche; Monia Deghrigue; Abderrahman Bouraoui
Journal:  Cancer Cell Int       Date:  2012-04-11       Impact factor: 5.722

2.  Zebrafish-based identification of the antiseizure nucleoside inosine from the marine diatom Skeletonema marinoi.

Authors:  Théo Brillatz; Chiara Lauritano; Maxime Jacmin; Supitcha Khamma; Laurence Marcourt; Davide Righi; Giovanna Romano; Francesco Esposito; Adrianna Ianora; Emerson F Queiroz; Jean-Luc Wolfender; Alexander D Crawford
Journal:  PLoS One       Date:  2018-04-24       Impact factor: 3.240

3.  Magnificines A and B, Antimicrobial Marine Alkaloids Featuring a Tetrahydrooxazolo[3,2-a]azepine-2,5(3H,6H)-dione Backbone from the Red Sea Sponge Negombata magnifica.

Authors:  Diaa T A Youssef; Hani Z Asfour; Grégory Genta-Jouve; Lamiaa A Shaala
Journal:  Mar Drugs       Date:  2021-04-12       Impact factor: 5.118

Review 4.  Natural Products Repertoire of the Red Sea.

Authors:  Ebaa M El-Hossary; Mohammad Abdel-Halim; Eslam S Ibrahim; Sheila Marie Pimentel-Elardo; Justin R Nodwell; Heba Handoussa; Miada F Abdelwahab; Ulrike Holzgrabe; Usama Ramadan Abdelmohsen
Journal:  Mar Drugs       Date:  2020-09-04       Impact factor: 5.118
  4 in total

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