Literature DB >> 15217296

A new dimension to the biosynthetic products isolated from the sponge Negombata magnifica.

Boaz Vilozny1, Taro Amagata, Susan L Mooberry, Phillip Crews.   

Abstract

Latrunculeic acid (3), a novel analogue of latrunculin B (2a), was isolated from the Red Sea sponge Negombata magnifica and characterized. Several known compounds were also isolated, including latrunculin B (2a), 15-methoxylatrunculin B (2b), 16-epi-latrunculin B (4), and latrunculin C (5). In contrast to the other members of the latrunculin family, the novel compound 3 is a polyketide devoid of the normal macrocyclic and thiazolidinone rings present in previously identified members of this family.

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Year:  2004        PMID： 15217296     DOI： 10.1021/np0340753

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  7 in total

1.  Diverted total synthesis: preparation of a focused library of latrunculin analogues and evaluation of their actin-binding properties.

Authors:  Alois Fürstner; Douglas Kirk; Michaël D B Fenster; Christophe Aïssa; Dominic De Souza; Oliver Müller
Journal:  Proc Natl Acad Sci U S A       Date:  2005-05-25       Impact factor: 11.205

2.  A reassignment of (-)-mycothiazole and the isolation of a related diol.

Authors:  Rachel N Sonnenschein; Tyler A Johnson; Karen Tenney; Frederick A Valeriote; Phillip Crews
Journal:  J Nat Prod       Date:  2006-01       Impact factor: 4.050

3.  Antiepileptic ceramides from the Red Sea sponge Negombata corticata.

Authors:  Safwat A Ahmed; Sherief I Khalifa; Mark T Hamann
Journal:  J Nat Prod       Date:  2008-03-21       Impact factor: 4.050

4.  Interrogating the bioactive pharmacophore of the latrunculin chemotype by investigating the metabolites of two taxonomically unrelated sponges.

Authors:  Taro Amagata; Tyler A Johnson; Robert H Cichewicz; Karen Tenney; Susan L Mooberry; Joseph Media; Matthew Edelstein; Frederick A Valeriote; Phillip Crews
Journal:  J Med Chem       Date:  2008-11-27       Impact factor: 7.446

5.  Semisynthetic latrunculin B analogs: studies of actin docking support a proposed mechanism for latrunculin bioactivity.

Authors:  Sucheta Kudrimoti; Safwat A Ahmed; Pankaj R Daga; Amir E Wahba; Sherief I Khalifa; Robert J Doerksen; Mark T Hamann
Journal:  Bioorg Med Chem       Date:  2009-09-16       Impact factor: 3.641

6.  Magnificines A and B, Antimicrobial Marine Alkaloids Featuring a Tetrahydrooxazolo[3,2-a]azepine-2,5(3H,6H)-dione Backbone from the Red Sea Sponge Negombata magnifica.

Authors:  Diaa T A Youssef; Hani Z Asfour; Grégory Genta-Jouve; Lamiaa A Shaala
Journal:  Mar Drugs       Date:  2021-04-12       Impact factor: 5.118

Review 7.  Natural Products Repertoire of the Red Sea.

Authors:  Ebaa M El-Hossary; Mohammad Abdel-Halim; Eslam S Ibrahim; Sheila Marie Pimentel-Elardo; Justin R Nodwell; Heba Handoussa; Miada F Abdelwahab; Ulrike Holzgrabe; Usama Ramadan Abdelmohsen
Journal:  Mar Drugs       Date:  2020-09-04       Impact factor: 5.118
  7 in total

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