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Literature DB >> 1835480

Anti-CD3- or PHA-induced cytotoxicity in human intraepithelial and lamina propria lymphocytes.

Abstract

Morphological data in humans and rodents and functional data of intraepithelial lymphocytes of mice support the idea that cytotoxic cells are a significant population of the human mucosa. Previously it was shown that human IEL have no spontaneous cell-mediated cytotoxicity and that human LPL cells have anti-CD3-mediated cytotoxicity. We confirm that most individuals have anti-CD3- or PHA-mediated cytotoxicity of LPL. In IEL we do not find cytotoxic function in short-term assays. There is no difference between patients with colon cancer and inflammatory bowel disease.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 1991 PMID： 1835480 DOI： 10.1007/bf02919697

Source DB: PubMed Journal: Immunol Res ISSN： 0257-277X Impact factor: 2.829

14 in total

1. Mucosal T cells provide helper function but do not proliferate when stimulated by specific antigen in lymphogranuloma venereum proctitis in nonhuman primates.

Authors: M Zeitz; T C Quinn; A S Graeff; S P James
Journal: Gastroenterology Date: 1988-02 Impact factor: 22.682

2. [Intestinal spontaneous cell-mediated cytotoxicity and its immunoregulation in patients with chronic inflammatory bowel disease and controls].

Authors: I O Auer; J Rüthlein; A Röder; C Reineke; K Grudzinsky
Journal: Immun Infekt Date: 1986-02

3. A monoclonal antibody (HML-1) defining a novel membrane molecule present on human intestinal lymphocytes.

Authors: N Cerf-Bensussan; A Jarry; N Brousse; B Lisowska-Grospierre; D Guy-Grand; C Griscelli
Journal: Eur J Immunol Date: 1987-09 Impact factor: 5.532

Review 4. Immunologic mechanisms in intestinal diseases.

Authors: S R Targan; M F Kagnoff; M D Brogan; F Shanahan
Journal: Ann Intern Med Date: 1987-06 Impact factor: 25.391

5. Natural killer cells and spontaneous cell-mediated cytotoxicity in the human intestine.

Authors: P R Gibson; E L Dow; W S Selby; R G Strickland; D P Jewell
Journal: Clin Exp Immunol Date: 1984-05 Impact factor: 4.330

6. Human intestinal mononuclear cells. I. Investigation of antibody-dependent, lectin-induced, and spontaneous cell-mediated cytotoxic capabilities.

Authors: R P MacDermott; G O Franklin; K M Jenkins; I J Kodner; G S Nash; I J Weinrieb
Journal: Gastroenterology Date: 1980-01 Impact factor: 22.682

Anti-CD3- or PHA-induced cytotoxicity in human intraepithelial and lamina propria lymphocytes.

1. Mucosal T cells provide helper function but do not proliferate when stimulated by specific antigen in lymphogranuloma venereum proctitis in nonhuman primates.

2. [Intestinal spontaneous cell-mediated cytotoxicity and its immunoregulation in patients with chronic inflammatory bowel disease and controls].

3. A monoclonal antibody (HML-1) defining a novel membrane molecule present on human intestinal lymphocytes.

Review 4. Immunologic mechanisms in intestinal diseases.

5. Natural killer cells and spontaneous cell-mediated cytotoxicity in the human intestine.

6. Human intestinal mononuclear cells. I. Investigation of antibody-dependent, lectin-induced, and spontaneous cell-mediated cytotoxic capabilities.

7. Human colonic mononuclear cells: studies of cytotoxic function.

8. Peripheral, mucosal, and tumour-infiltrating components of cellular immunity in cancer of the large bowel.

9. Intraepithelial lymphocytes of human gut: isolation, characterisation and study of natural killer activity.

10. Characteristics of natural killer cells in the murine intestinal epithelium and lamina propria.

1. Anti-CD2 and anti-CD3 induced T cell cytotoxicity of human intraepithelial and lamina propria lymphocytes.