Literature DB >> 18347952

On the possibility of silicon nitride as a ceramic for structural orthopaedic implants. Part I: processing, microstructure, mechanical properties, cytotoxicity.

Mauro Mazzocchi1, Alida Bellosi.   

Abstract

Notwithstanding the good combination of mechanical and tribological properties, the suitability of silicon nitride for application as prosthesis in bone reconstruction or in articular joints replacements is still controversial. This study aims to design and produce three different silicon nitride-based ceramics and to test the materials. In this Part I the microstructure and mechanical properties evidence outstanding characteristics and the cytotoxicity studies confirm that all the materials are extremely inert and biocompatible. In Part II, the wear performance and the wettability and chemical stability against different aqueous media and physiological solutions are investigated and discussed.

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Year:  2008        PMID: 18347952     DOI: 10.1007/s10856-008-3417-2

Source DB:  PubMed          Journal:  J Mater Sci Mater Med        ISSN: 0957-4530            Impact factor:   3.896


  13 in total

1.  Densification route and mechanical properties of Si3N4-bioglass biocomposites.

Authors:  M Amaral; M A Lopes; R F Silva; J D Santos
Journal:  Biomaterials       Date:  2002-02       Impact factor: 12.479

2.  Protein adsorption onto two bioactive glass-ceramics.

Authors:  A Rosengren; S Oscarsson; M Mazzocchi; A Krajewski; A Ravaglioli
Journal:  Biomaterials       Date:  2003-01       Impact factor: 12.479

3.  Biocompatibility of silicon-based arrays of electrodes coupled to organotypic hippocampal brain slice cultures.

Authors:  B W Kristensen; J Noraberg; P Thiébaud; M Koudelka-Hep; J Zimmer
Journal:  Brain Res       Date:  2001-03-30       Impact factor: 3.252

4.  Osteointegration of bioactive glass-coated zirconia in healthy bone: an in vivo evaluation.

Authors:  V Stanic; N Nicoli Aldini; M Fini; G Giavaresi; R Giardino; A Krajewski; A Ravaglioli; M Mazzocchi; B Dubini; M G Ponzi Bossi; F Rustichelli
Journal:  Biomaterials       Date:  2002-09       Impact factor: 12.479

5.  Evaluation of MEMS materials of construction for implantable medical devices.

Authors:  Geoffrey Kotzar; Mark Freas; Phillip Abel; Aaron Fleischman; Shuvo Roy; Christian Zorman; James M Moran; Jeff Melzak
Journal:  Biomaterials       Date:  2002-07       Impact factor: 12.479

6.  [Biocompatibilty of silicon nitride ceramic in vitro. A comparative fluorescence-microscopic and scanning electron-microscopic study].

Authors:  A Neumann; K Jahnke; H R Maier; C Ragoss
Journal:  Laryngorhinootologie       Date:  2004-12       Impact factor: 1.057

7.  Proinflammatory cytokine expression of IL-1beta and TNF-alpha by human osteoblast-like MG-63 cells upon exposure to silicon nitride in vitro.

Authors:  A Sohrabi; C Holland; R Kue; D Nagle; D S Hungerford; C G Frondoza
Journal:  J Biomed Mater Res       Date:  2000-04

8.  Enhanced proliferation and osteocalcin production by human osteoblast-like MG63 cells on silicon nitride ceramic discs.

Authors:  R Kue; A Sohrabi; D Nagle; C Frondoza; D Hungerford
Journal:  Biomaterials       Date:  1999-07       Impact factor: 12.479

9.  Improvement in zirconia osseointegration by means of a biological glass coating: An in vitro and in vivo investigation.

Authors:  N Nicoli Aldini; M Fini; G Giavaresi; P Torricelli; L Martini; R Giardino; A Ravaglioli; A Krajewski; M Mazzocchi; B Dubini; M G Ponzi-Bossi; F Rustichelli; V Stanic
Journal:  J Biomed Mater Res       Date:  2002-08

10.  Characterization of proteins and fibroblasts on thin inorganic films.

Authors:  Constantina S Giannoulis; Tejal A Desai
Journal:  J Mater Sci Mater Med       Date:  2002-01       Impact factor: 3.896

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  8 in total

1.  Artifact level produced by different femoral head prostheses in CT imaging: diamond coated silicon nitride as total hip replacement material.

Authors:  Simone P Rodrigues; José M Paiva; Silvia De Francesco; Margarida I Amaral; Filipe J Oliveira; Rui F Silva
Journal:  J Mater Sci Mater Med       Date:  2012-10-07       Impact factor: 3.896

2.  Silicon nitride enhances osteoprogenitor cell growth and differentiation via increased surface energy and formation of amide and nanocrystalline HA for craniofacial reconstruction.

Authors:  Kamal R Awad; Neelam Ahuja; Ami Shah; Henry Tran; Pranesh B Aswath; Marco Brotto; Venu Varanasi
Journal:  Med Devices Sens       Date:  2019-05-06

Review 3.  Silicon Nitride as a Biomedical Material: An Overview.

Authors:  Xiaoyu Du; Seunghun S Lee; Gurdial Blugan; Stephen J Ferguson
Journal:  Int J Mol Sci       Date:  2022-06-11       Impact factor: 6.208

4.  Promoting osteoblasts responses in vitro and improving osteointegration in vivo through bioactive coating of nanosilicon nitride on polyetheretherketone.

Authors:  Yong Dai; Han Guo; Linyang Chu; Zihao He; Minqi Wang; Shuhong Zhang; Xifu Shang
Journal:  J Orthop Translat       Date:  2019-11-21       Impact factor: 5.191

Review 5.  An overview of recent advances in designing orthopedic and craniofacial implants.

Authors:  Venkata P Mantripragada; Beata Lecka-Czernik; Nabil A Ebraheim; Ambalangodage C Jayasuriya
Journal:  J Biomed Mater Res A       Date:  2013-06-14       Impact factor: 4.396

6.  The SNAP trial: a double blind multi-center randomized controlled trial of a silicon nitride versus a PEEK cage in transforaminal lumbar interbody fusion in patients with symptomatic degenerative lumbar disc disorders: study protocol.

Authors:  Roel F M R Kersten; Steven M van Gaalen; Mark P Arts; Kit C B Roes; Arthur de Gast; Terry P Corbin; F Cumhur Öner
Journal:  BMC Musculoskelet Disord       Date:  2014-02-25       Impact factor: 2.362

7.  The Effect of Coating Density on Functional Properties of SiNx Coated Implants.

Authors:  Luimar Correa Filho; Susann Schmidt; Alejandro López; Mathilde Cogrel; Klaus Leifer; Håkan Engqvist; Hans Högberg; Cecilia Persson
Journal:  Materials (Basel)       Date:  2019-10-15       Impact factor: 3.623

8.  Clinical outcomes for anterior cervical discectomy and fusion with silicon nitride spine cages: a multicenter study.

Authors:  Graham C Calvert; George VanBuren Huffmon; William M Rambo; Micah W Smith; Bryan J McEntire; B Sonny Bal
Journal:  J Spine Surg       Date:  2019-12
  8 in total

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