Literature DB >> 18347236

Epidemiology and risk factors for pathologic scarring after burn wounds.

Ezio Nicola Gangemi1, Dario Gregori, Paola Berchialla, Enrico Zingarelli, Monica Cairo, Daniele Bollero, Jamal Ganem, Roberto Capocelli, Franca Cuccuru, Pompeo Cassano, Daniela Risso, Maurizio Stella.   

Abstract

OBJECTIVE: To describe the clinical characteristics of postburn scars and determine the independent risk factors specific to these patients. While burns may generate widespread and disfiguring scars and have a dramatic influence on patient quality of life, the prevalence of postburn pathologic scarring is not well documented, and the impact of certain risk factors is poorly understood.
METHODS: A retrospective analysis was conducted of the clinical records of 703 patients (2440 anatomic burn sites) treated at the Turin Burn Outpatient Clinic between January 1994 and May 15, 2006. Prevalence and evolution time of postburn pathologic scarring were analyzed with univariate and multivariate risk factor analysis by sex, age, burn surface and full-thickness area, cause of the burn, wound healing time, type of burn treatment, number of surgical procedures, type of surgery, type of skin graft, and excision and graft timing.
RESULTS: Pathologic scarring was diagnosed in 540 patients (77%): 310 had hypertrophic scars (44%); 34, contractures (5%); and 196, hypertrophic-contracted scars (28%). The hypertrophic induction was assessed at a median of 23 days after reepithelialization and lasted 15 months (median). A nomogram, based on the multivariate regression model, showed that female sex, young age, burn sites on the neck and/or upper limbs, multiple surgical procedures, and meshed skin grafts were independent risk factors for postburn pathologic scarring (Dxy 0.30).
CONCLUSION: The identification of the principal risk factors for postburn pathologic scarring not only would be a valuable aid in early risk stratification but also might help in assessing outcomes adjusted for patient risk.

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Year:  2008        PMID: 18347236     DOI: 10.1001/archfaci.10.2.93

Source DB:  PubMed          Journal:  Arch Facial Plast Surg        ISSN: 1521-2491


  45 in total

1.  Ultrapulsed fractional ablative carbon dioxide laser treatment of hypertrophic burn scars: evaluation of an in-patient controlled, standardized treatment approach.

Authors:  Julian Poetschke; Ulf Dornseifer; Matteo Tretti Clementoni; Markus Reinholz; Hannah Schwaiger; Stephanie Steckmeier; Thomas Ruzicka; Gerd G Gauglitz
Journal:  Lasers Med Sci       Date:  2017-04-12       Impact factor: 3.161

2.  The cost of post-burn scarring.

Authors:  U Mirastschijski; J T Sander; U Zier; H O Rennekampff; B Weyand; P M Vogt
Journal:  Ann Burns Fire Disasters       Date:  2015-09-30

3.  The modified Patient and Observer Scar Assessment Scale: a novel approach to defining pathologic and nonpathologic scarring.

Authors:  Regina M Fearmonti; Jennifer E Bond; Detlev Erdmann; L Scott Levin; Salvatore V Pizzo; Howard Levinson
Journal:  Plast Reconstr Surg       Date:  2011-01       Impact factor: 4.730

4.  Clodronate liposomes reduce excessive scar formation in a mouse model of burn injury by reducing collagen deposition and TGF-β1 expression.

Authors:  Shao-Wei Lu; Xing-Mei Zhang; Hong-Min Luo; Yu-Cai Fu; Ming-Yan Xu; Shi-Jie Tang
Journal:  Mol Biol Rep       Date:  2014-01-19       Impact factor: 2.316

5.  [Post-burn cervical retractions: 45 cases and a survey of the literature].

Authors:  D Elamrani; A Zahid; N Aboujaafr; M Diouri; N Bahechar; E H Boukind
Journal:  Ann Burns Fire Disasters       Date:  2011-09-30

6.  Artiss® and burn treatment: a retrospective analysis contributing to current clinical practice.

Authors:  Liza Van Kerckhoven; Margot Den Hondt; Michel Van Brussel; Jan Vranckx
Journal:  Int J Burns Trauma       Date:  2020-04-15

Review 7.  Hypertrophic Scarring: Current Knowledge of Predisposing Factors, Cellular and Molecular Mechanisms.

Authors:  Layla Nabai; Amir Pourghadiri; Aziz Ghahary
Journal:  J Burn Care Res       Date:  2020-01-30       Impact factor: 1.845

8.  The Patient and Observer Scar Assessment Scale: Translation for portuguese language, cultural adaptation, and validation.

Authors:  Lgs Lenzi; Jbg Santos; J Raduan Neto; C H Fernandes; F Faloppa
Journal:  Int Wound J       Date:  2019-10-09       Impact factor: 3.315

9.  The role of the TGF-β family in wound healing, burns and scarring: a review.

Authors:  Jack W Penn; Adriaan O Grobbelaar; Kerstin J Rolfe
Journal:  Int J Burns Trauma       Date:  2012-02-05

10.  Effects of laser irradiation (670-nm InGaP and 830-nm GaAlAs) on burn of second-degree in rats.

Authors:  Gabriela Bortolança Chiarotto; Lia Mara Grosso Neves; Marcelo Augusto Marreto Esquisatto; Maria Esméria Corezola do Amaral; Gláucia Maria Tech dos Santos; Fernanda Aparecida Sampaio Mendonça
Journal:  Lasers Med Sci       Date:  2014-04-13       Impact factor: 3.161

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