| Literature DB >> 18345680 |
Patrice Fontaine1, Angèle Chiaroni, Géraldine Masson, Jieping Zhu.
Abstract
The reaction of aldehydes, amines, and TMSCN in the presence of 2-iodoxybenzoic acid (IBX) and tetrabutylammonium bromide (TBAB) afforded alpha-iminonitriles in good to excellent yields under mild conditions. The presence of TBAB is essential for this transformation. The methodology was applied to a two-step synthesis of indolizidine via a microwave-assisted intramolecular cycloaddition of alpha-iminonitrile.Entities:
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Year: 2008 PMID： 18345680 DOI： 10.1021/ol800199b
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005