Literature DB >> 18343108

Synthesis of barbiturate-based methionine aminopeptidase-1 inhibitors.

Manas K Haldar1, Michael D Scott, Nitesh Sule, D K Srivastava, Sanku Mallik.   

Abstract

The syntheses of a new class of barbiturate-based inhibitors for human and Escherichia Coli methionine aminopeptidase-1 (MetAP-1) are described. Some of the synthesized inhibitors show selective inhibition of the human enzyme with high potency.

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Year:  2008        PMID： 18343108      PMCID： PMC2390822          DOI： 10.1016/j.bmcl.2008.02.066

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  21 in total

1.  A novel methionine aminopeptidase-2 inhibitor, PPI-2458, inhibits non-Hodgkin's lymphoma cell proliferation in vitro and in vivo.

Authors:  Andrew C Cooper; Russell M Karp; Edward J Clark; Nazbeh R Taghizadeh; Jennifer G Hoyt; Matthew T Labenski; Michael J Murray; Gerhard Hannig; William F Westlin; Charles D Thompson
Journal:  Clin Cancer Res       Date:  2006-04-15       Impact factor: 12.531

2.  Elucidation of the function of type 1 human methionine aminopeptidase during cell cycle progression.

Authors:  Xiaoyi Hu; Anthony Addlagatta; Jun Lu; Brian W Matthews; Jun O Liu
Journal:  Proc Natl Acad Sci U S A       Date:  2006-11-17       Impact factor: 11.205

3.  Structural basis for the functional differences between type I and type II human methionine aminopeptidases.

Authors:  Anthony Addlagatta; Xiaoyi Hu; Jun O Liu; Brian W Matthews
Journal:  Biochemistry       Date:  2005-11-15       Impact factor: 3.162

4.  Serendipitous discovery of novel bacterial methionine aminopeptidase inhibitors.

Authors:  Artem G Evdokimov; Matthew Pokross; Richard L Walter; Marlene Mekel; Bobby L Barnett; Jack Amburgey; William L Seibel; Shari J Soper; Jane F Djung; Neil Fairweather; Conrad Diven; Vinit Rastogi; Leo Grinius; Charles Klanke; Richard Siehnel; Tracy Twinem; Ryan Andrews; Alan Curnow
Journal:  Proteins       Date:  2007-02-15

5.  Identification of pyridinylpyrimidines as inhibitors of human methionine aminopeptidases.

Authors:  Xiaoyi Hu; Anthony Addlagatta; Brian W Matthews; Jun O Liu
Journal:  Angew Chem Int Ed Engl       Date:  2006-06-02       Impact factor: 15.336

6.  Metal mediated inhibition of methionine aminopeptidase by quinolinyl sulfonamides.

Authors:  Min Huang; Sheng-Xue Xie; Ze-Qiang Ma; Robert P Hanzlik; Qi-Zhuang Ye
Journal:  Biochem Biophys Res Commun       Date:  2005-11-15       Impact factor: 3.575

7.  Structure of the angiogenesis inhibitor ovalicin bound to its noncognate target, human Type 1 methionine aminopeptidase.

Authors:  Anthony Addlagatta; Brian W Matthews
Journal:  Protein Sci       Date:  2006-07-05       Impact factor: 6.725

8.  The proteomics of N-terminal methionine cleavage.

Authors:  Frédéric Frottin; Aude Martinez; Philippe Peynot; Sanghamitra Mitra; Richard C Holz; Carmela Giglione; Thierry Meinnel
Journal:  Mol Cell Proteomics       Date:  2006-09-08       Impact factor: 5.911

9.  Inhibitors of Plasmodium falciparum methionine aminopeptidase 1b possess antimalarial activity.

Authors:  Xiaochun Chen; Curtis R Chong; Lirong Shi; Tadashi Yoshimoto; David J Sullivan; Jun O Liu
Journal:  Proc Natl Acad Sci U S A       Date:  2006-09-18       Impact factor: 11.205

10.  Metal-mediated inhibition of Escherichia coli methionine aminopeptidase: structure-activity relationships and development of a novel scoring function for metal-ligand interactions.

Authors:  Rolf Schiffmann; Alexander Neugebauer; Christian D Klein
Journal:  J Med Chem       Date:  2006-01-26       Impact factor: 7.446
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  10 in total

1.  Bridging of a substrate between cyclodextrin and an enzyme's active site pocket triggers a unique mode of inhibition.

Authors:  Nitesh V Sule; Angel Ugrinov; Sanku Mallik; D K Srivastava
Journal:  Biochim Biophys Acta       Date:  2014-10-24

2.  Probing the metal ion selectivity in methionine aminopeptidase via changes in the luminescence properties of the enzyme bound europium ion.

Authors:  Nitesh Sule; Raushan K Singh; Pinjing Zhao; D K Srivastava
Journal:  J Inorg Biochem       Date:  2011-09-22       Impact factor: 4.155

3.  Fluorescent polymer-based post-translational differentiation and subtyping of breast cancer cells.

Authors:  Michael D Scott; Rinku Dutta; Manas K Haldar; Anil Wagh; Thomas R Gustad; Benedict Law; Daniel L Friesner; Sanku Mallik
Journal:  Analyst       Date:  2012-10-12       Impact factor: 4.616

4.  Pyridinylpyrimidines selectively inhibit human methionine aminopeptidase-1.

Authors:  Pengtao Zhang; Xinye Yang; Feiran Zhang; Sandra B Gabelli; Renxiao Wang; Yihua Zhang; Shridhar Bhat; Xiaochun Chen; Manuel Furlani; L Mario Amzel; Jun O Liu; Dawei Ma
Journal:  Bioorg Med Chem       Date:  2013-02-21       Impact factor: 3.641

Review 5.  Advances in Bacterial Methionine Aminopeptidase Inhibition.

Authors:  Travis R Helgren; Phumvadee Wangtrakuldee; Bart L Staker; Timothy J Hagen
Journal:  Curr Top Med Chem       Date:  2016       Impact factor: 3.295

6.  Pyridinylquinazolines selectively inhibit human methionine aminopeptidase-1 in cells.

Authors:  Feiran Zhang; Shridhar Bhat; Sandra B Gabelli; Xiaochun Chen; Michelle S Miller; Benjamin A Nacev; Yim Ling Cheng; David J Meyers; Karen Tenney; Joong Sup Shim; Phillip Crews; L Mario Amzel; Dawei Ma; Jun O Liu
Journal:  J Med Chem       Date:  2013-05-01       Impact factor: 7.446

7.  Antibacterial, antiurease, and antioxidant activities of some arylidene barbiturates.

Authors:  Bahar Bilgin Sokmen; Serpil Ugras; Hasan Yucel Sarikaya; Halil Ibrahim Ugras; Refiye Yanardag
Journal:  Appl Biochem Biotechnol       Date:  2013-09-11       Impact factor: 2.926

8.  P1' Residue-Oriented Virtual Screening for Potent and Selective Phosphinic (Dehydro) Dipeptide Inhibitors of Metallo-Aminopeptidases.

Authors:  Michał Talma; Artur Mucha
Journal:  Biomolecules       Date:  2020-04-24

9.  Green Synthesis and Urease Inhibitory Activity of Spiro-Pyrimidinethiones/Spiro-Pyrimidinones-Barbituric Acid Derivatives.

Authors:  Ghodsi Mohammadi Ziarani; Shima Asadi; Sakineh Faramarzi; Massoud Amanlou
Journal:  Iran J Pharm Res       Date:  2015       Impact factor: 1.696

10.  Role of the Substrate Specificity-Defining Residues of Human SIRT5 in Modulating the Structural Stability and Inhibitory Features of the Enzyme.

Authors:  Junru Yu; Manas Haldar; Sanku Mallik; D K Srivastava
Journal:  PLoS One       Date:  2016-03-29       Impact factor: 3.240
  10 in total

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