BACKGROUND: Obsessive-compulsive disorder (OCD) is a clinically heterogenous disorder characterized by temporally stable symptom dimensions. Past inconsistent results from structural neuroimaging studies of OCD may have resulted from the effects of these specific symptom dimensions as well as other socio-demographic and clinical variables upon gray matter (GM) volume. METHODS: GM volume was measured in 25 adult OCD patients and 20 adult healthy controls using voxel-based morphometry (VBM), controlling for age and total brain GM volume. Univariate and multivariate regression analyses were carried out between regions of GM difference and age, age of onset, medication load, OCD severity, depression severity, and separate symptom dimension scores. RESULTS: Significant GM volumetric differences in OCD patients relative to controls were found in dorsal cortical regions, including bilateral BA6, BA46, BA9 and right BA8 (controls>patients), and bilateral midbrain (patients>controls). Stepwise regression analyses revealed highly significant relationships between greater total OCD symptom severity and smaller GM volumes in dorsal cortical regions and larger GM volumes in bilateral midbrain. Greater age was independently associated with smaller GM volumes in right BA6, left BA9, left BA46 and larger GM volumes in right midbrain. Greater washing symptom severity was independently associated with smaller GM volume in right BA6, while there was a trend association between greater hoarding symptom severity and lower GM volume in left BA6. LIMITATIONS: The sample was relatively small to examine the relationship between symptom scores and GM volumes. Multiple patients were taking medication and had comorbid disorders. CONCLUSIONS: These analyses suggest dorsal prefrontal cortical and bilateral midbrain GM abnormalities in OCD that appear to be primarily driven by the effects of total OCD symptom severity. The results regarding the relationship between GM volumes and symptom dimension scores require examination in larger samples.
BACKGROUND:Obsessive-compulsive disorder (OCD) is a clinically heterogenous disorder characterized by temporally stable symptom dimensions. Past inconsistent results from structural neuroimaging studies of OCD may have resulted from the effects of these specific symptom dimensions as well as other socio-demographic and clinical variables upon gray matter (GM) volume. METHODS: GM volume was measured in 25 adult OCDpatients and 20 adult healthy controls using voxel-based morphometry (VBM), controlling for age and total brain GM volume. Univariate and multivariate regression analyses were carried out between regions of GM difference and age, age of onset, medication load, OCD severity, depression severity, and separate symptom dimension scores. RESULTS: Significant GM volumetric differences in OCDpatients relative to controls were found in dorsal cortical regions, including bilateral BA6, BA46, BA9 and right BA8 (controls>patients), and bilateral midbrain (patients>controls). Stepwise regression analyses revealed highly significant relationships between greater total OCD symptom severity and smaller GM volumes in dorsal cortical regions and larger GM volumes in bilateral midbrain. Greater age was independently associated with smaller GM volumes in right BA6, left BA9, left BA46 and larger GM volumes in right midbrain. Greater washing symptom severity was independently associated with smaller GM volume in right BA6, while there was a trend association between greater hoarding symptom severity and lower GM volume in left BA6. LIMITATIONS: The sample was relatively small to examine the relationship between symptom scores and GM volumes. Multiple patients were taking medication and had comorbid disorders. CONCLUSIONS: These analyses suggest dorsal prefrontal cortical and bilateral midbrain GM abnormalities in OCD that appear to be primarily driven by the effects of total OCD symptom severity. The results regarding the relationship between GM volumes and symptom dimension scores require examination in larger samples.
Authors: Brett Froeliger; Rachel V Kozink; Jed E Rose; Frederique M Behm; Alfred N Salley; F Joseph McClernon Journal: Psychopharmacology (Berl) Date: 2010-04-28 Impact factor: 4.530
Authors: Carly M Schwartzman; Christina L Boisseau; Nicholas J Sibrava; Maria C Mancebo; Jane L Eisen; Steven A Rasmussen Journal: Psychiatry Res Date: 2017-01-20 Impact factor: 3.222
Authors: Ewgeni Jakubovski; Christopher Pittenger; Albina Rodrigues Torres; Leonardo Franklin Fontenelle; Maria Conceicao do Rosario; Ygor Arzeno Ferrão; Maria Alice de Mathis; Euripedes Constantino Miguel; Michael H Bloch Journal: Prog Neuropsychopharmacol Biol Psychiatry Date: 2011-05-27 Impact factor: 5.067
Authors: Christina M Hough; Tracy L Luks; Karen Lai; Ofilio Vigil; Sylvia Guillory; Arvind Nongpiur; Shiva M Fekri; Eve Kupferman; Daniel H Mathalon; Carol A Mathews Journal: Psychiatry Res Neuroimaging Date: 2016-07-12 Impact factor: 2.376
Authors: Alison J Athey; Jason A Elias; Jesse M Crosby; Michael A Jenike; Harrison G Pope; James I Hudson; Brian P Brennan Journal: J Obsessive Compuls Relat Disord Date: 2015-01-01 Impact factor: 1.677
Authors: Amelia Versace; Jorge R C Almeida; Stefanie Hassel; Nicholas D Walsh; Massimiliano Novelli; Crystal R Klein; David J Kupfer; Mary L Phillips Journal: Arch Gen Psychiatry Date: 2008-09
Authors: Michael H Bloch; Brittany G Craiglow; Angeli Landeros-Weisenberger; Philip A Dombrowski; Kaitlyn E Panza; Bradley S Peterson; James F Leckman Journal: Pediatrics Date: 2009-09-28 Impact factor: 7.124