OBJECTIVES: To identify the variables that predict death/physiologic bronchopulmonary dysplasia (BPD) in preterm infants with severe respiratory failure. STUDY DESIGN: The study was a secondary analysis of data from the NICHD Neonatal Research Network trial of inhaled nitric oxide (iNO) in preterm infants. Stepwise logistic regression models and Classification and Regression Tree (CART) models were developed for the outcome of death or physiologic BPD (O(2) at 36 weeks post-menstrual age). RESULT: Death and/or BPD was associated with lower birth weight, higher oxygen requirement, male gender, additional surfactant doses, higher oxygenation index and outborn status, but not the magnitude of response in PaO(2) to iNO. The positive predictive value of the CART model was 82% at 95% sensitivity. CONCLUSIONS: The major factors associated with death/BPD were an increased severity of respiratory failure, lower birth weight, male gender and outborn status, but not the magnitude of initial response to iNO.
OBJECTIVES: To identify the variables that predict death/physiologic bronchopulmonary dysplasia (BPD) in preterm infants with severe respiratory failure. STUDY DESIGN: The study was a secondary analysis of data from the NICHD Neonatal Research Network trial of inhaled nitric oxide (iNO) in preterm infants. Stepwise logistic regression models and Classification and Regression Tree (CART) models were developed for the outcome of death or physiologic BPD (O(2) at 36 weeks post-menstrual age). RESULT: Death and/or BPD was associated with lower birth weight, higher oxygen requirement, male gender, additional surfactant doses, higher oxygenation index and outborn status, but not the magnitude of response in PaO(2) to iNO. The positive predictive value of the CART model was 82% at 95% sensitivity. CONCLUSIONS: The major factors associated with death/BPD were an increased severity of respiratory failure, lower birth weight, male gender and outborn status, but not the magnitude of initial response to iNO.
Authors: John P Kinsella; Gary R Cutter; William F Walsh; Dale R Gerstmann; Carl L Bose; Claudia Hart; Kris C Sekar; Richard L Auten; Vinod K Bhutani; Jeffrey S Gerdes; Thomas N George; W Michael Southgate; Heather Carriedo; Robert J Couser; Mark C Mammel; David C Hall; Mariann Pappagallo; Smeeta Sardesai; John D Strain; Monika Baier; Steven H Abman Journal: N Engl J Med Date: 2006-07-27 Impact factor: 91.245
Authors: Krisa P Van Meurs; Linda L Wright; Richard A Ehrenkranz; James A Lemons; M Bethany Ball; W Kenneth Poole; Rebecca Perritt; Rosemary D Higgins; William Oh; Mark L Hudak; Abbot R Laptook; Seetha Shankaran; Neil N Finer; Waldemar A Carlo; Kathleen A Kennedy; Jon H Fridriksson; Robin H Steinhorn; Gregory M Sokol; G Ganesh Konduri; Judy L Aschner; Barbara J Stoll; Carl T D'Angio; David K Stevenson Journal: N Engl J Med Date: 2005-07-07 Impact factor: 91.245
Authors: Michael D Schreiber; Karen Gin-Mestan; Jeremy D Marks; Dezheng Huo; Grace Lee; Pimol Srisuparp Journal: N Engl J Med Date: 2003-11-27 Impact factor: 91.245
Authors: Yvette N Martin; Logan Manlove; Jie Dong; William A Carey; Michael A Thompson; Christina M Pabelick; Hitesh C Pandya; Richard J Martin; Dennis A Wigle; Y S Prakash Journal: Am J Physiol Lung Cell Mol Physiol Date: 2014-11-14 Impact factor: 5.464
Authors: Cameron F Gunville; Marci K Sontag; Kristin A Stratton; Daksha J Ranade; Steven H Abman; Peter M Mourani Journal: J Pediatr Date: 2010-03-24 Impact factor: 4.406
Authors: Colm P Travers; Waldemar A Carlo; Scott A McDonald; Abhik Das; Edward F Bell; Namasivayam Ambalavanan; Alan H Jobe; Ronald N Goldberg; Carl T D'Angio; Barbara J Stoll; Seetha Shankaran; Abbot R Laptook; Barbara Schmidt; Michele C Walsh; Pablo J Sánchez; M Bethany Ball; Ellen C Hale; Nancy S Newman; Rosemary D Higgins Journal: Am J Obstet Gynecol Date: 2017-11-11 Impact factor: 8.661
Authors: Katherine C Wai; Michael A Kohn; Roberta A Ballard; William E Truog; Dennis M Black; Jeanette M Asselin; Philip L Ballard; Elizabeth E Rogers; Roberta L Keller Journal: J Pediatr Date: 2016-07-26 Impact factor: 4.406
Authors: Bernard Thébaud; Kara N Goss; Matthew Laughon; Jeffrey A Whitsett; Steven H Abman; Robin H Steinhorn; Judy L Aschner; Peter G Davis; Sharon A McGrath-Morrow; Roger F Soll; Alan H Jobe Journal: Nat Rev Dis Primers Date: 2019-11-14 Impact factor: 52.329