Literature DB >> 1833208

Interaction of flunarizine with dopamine D2 and D1 receptors.

C Ambrosio1, E Stefanini.   

Abstract

Flunarizine dose dependently inhibits the binding of both [3H]spiperone and [3H]SCH 23390 with Ki values of 112 +/- 9 and 532 +/- 39 nM, respectively. The inhibition of [3H]spiperone binding by flunarizine was competitive as revealed by the Schild plot. The results indicate that flunarizine is a fairly potent dopamine D2 receptor antagonist and offer a possible explanation for the extrapyramidal side-effects observed in patients treated with the drug.

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Year:  1991        PMID： 1833208     DOI： 10.1016/0014-2999(91)90526-v

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  6 in total

1.  Influence of nicardipine, nimodipine and flunarizine on the anticonvulsant efficacy of antiepileptics against pentylenetetrazol in mice.

Authors:  M Gasior; R Kamiński; T Brudniak; Z Kleinrok; S J Czuczwar
Journal:  J Neural Transm (Vienna)       Date:  1996       Impact factor: 3.575

2.  Differential inhibition of T-type calcium channels by neuroleptics.

Authors:  Celia M Santi; Francisco S Cayabyab; Kathy G Sutton; John E McRory; Janette Mezeyova; Kevin S Hamming; David Parker; Anthony Stea; Terrance P Snutch
Journal:  J Neurosci       Date:  2002-01-15       Impact factor: 6.167

3.  Potent, extra-channel influence of several calcium-channel modulators on striatal binding of [3H]tyramine.

Authors:  A Vaccari; P Saba; G Gessa
Journal:  Neurochem Res       Date:  1993-11       Impact factor: 3.996

4.  Atypical antipsychotic profile of flunarizine in animal models.

Authors:  Adriano B L Tort; Oscar P Dall'Igna; Ricardo V de Oliveira; Carlos E A Mantese; Paulo Fett; Márcio W S Gomes; Juliana Schuh; Diogo O Souza; Diogo R Lara
Journal:  Psychopharmacology (Berl)       Date:  2004-07-28       Impact factor: 4.530

5.  Mitolysosome exocytosis, a mitophagy-independent mitochondrial quality control in flunarizine-induced parkinsonism-like symptoms.

Authors:  Feixiang Bao; Lingyan Zhou; Rui Zhou; Qiaoying Huang; Junguo Chen; Sheng Zeng; Yi Wu; Liang Yang; Shufang Qian; Mengfei Wang; Xueying He; Shan Liang; Juntao Qi; Ge Xiang; Qi Long; Jingyi Guo; Zhongfu Ying; Yanshuang Zhou; Qiuge Zhao; Jiwei Zhang; Di Zhang; Wei Sun; Mi Gao; Hao Wu; Yifan Zhao; Jinfu Nie; Min Li; Quan Chen; Jiekai Chen; Xiao Zhang; Guangjin Pan; Hong Zhang; Mingtao Li; Mei Tian; Xingguo Liu
Journal:  Sci Adv       Date:  2022-04-13       Impact factor: 14.136

6.  In Silico Repositioning of Dopamine Modulators with Possible Application to Schizophrenia: Pharmacophore Mapping, Molecular Docking and Molecular Dynamics Analysis.

Authors:  Melissa Mejia-Gutierrez; Bryan D Vásquez-Paz; Leonardo Fierro; Julio R Maza
Journal:  ACS Omega       Date:  2021-06-01
  6 in total

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