| Literature DB >> 18331795 |
Scott D Edmondson1, Lan Wei, Jinyou Xu, Jackie Shang, Shiyao Xu, Jianmei Pang, Ashok Chaudhary, Dennis C Dean, Huaibing He, Barbara Leiting, Kathryn A Lyons, Reshma A Patel, Sangita B Patel, Giovanna Scapin, Joseph K Wu, Maria G Beconi, Nancy A Thornberry, Ann E Weber.
Abstract
The synthesis, selectivity, rat pharmacokinetic profile, and drug metabolism profiles of a series of potent fluoroolefin-derived DPP-4 inhibitors (4) are reported. A radiolabeled fluoroolefin 33 was shown to possess a high propensity to form reactive metabolites, thus revealing a potential liability for this class of DPP-4 inhibitors.Entities:
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Year: 2008 PMID： 18331795 DOI： 10.1016/j.bmcl.2008.02.050
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823