Literature DB >> 18331030

Atomic structure of a short alpha-helix stabilized by a main chain hydrogen-bond surrogate.

Jie Liu1, Deyun Wang, Qi Zheng, Min Lu, Paramjit S Arora.   

Abstract

Herein we report the 1.15 A X-ray crystal structure of a short alpha-helix in which the N-terminal i and i + 4 main chain hydrogen bond is replaced with a carbon-carbon bond. The structure shows that the hydrogen-bond surrogate (HBS) derived alpha-helix truly resembles the structure of canonical alpha-helices and provides unequivocal support for our helix nucleation strategy.

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Year:  2008        PMID： 18331030     DOI： 10.1021/ja077704u

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  23 in total

1.  Parallel β-sheet secondary structure is stabilized and terminated by interstrand disulfide cross-linking.

Authors:  Aaron M Almeida; Rebecca Li; Samuel H Gellman
Journal:  J Am Chem Soc       Date:  2011-12-13       Impact factor: 15.419

2.  Solid-phase synthesis of short α-helices stabilized by the hydrogen bond surrogate approach.

Authors:  Anupam Patgiri; Monica Z Menzenski; Andrew B Mahon; Paramjit S Arora
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3.  Solid phase synthesis of hydrogen bond surrogate derived alpha-helices: resolving the case of a difficult amide coupling.

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4.  Synthesis of hydrogen-bond surrogate α-helices as inhibitors of protein-protein interactions.

Authors:  Stephen E Miller; Paul F Thomson; Paramjit S Arora
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5.  Effects of side chains in helix nucleation differ from helix propagation.

Authors:  Stephen E Miller; Andrew M Watkins; Neville R Kallenbach; Paramjit S Arora
Journal:  Proc Natl Acad Sci U S A       Date:  2014-04-21       Impact factor: 11.205

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Journal:  Nat Rev Drug Discov       Date:  2016-04-11       Impact factor: 84.694

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Journal:  J Phys Chem B       Date:  2012-01-23       Impact factor: 2.991

8.  Response of GWALP transmembrane peptides to changes in the tryptophan anchor positions.

Authors:  Vitaly V Vostrikov; Roger E Koeppe
Journal:  Biochemistry       Date:  2011-08-12       Impact factor: 3.162

Review 9.  Protein Domain Mimics as Modulators of Protein-Protein Interactions.

Authors:  Nicholas Sawyer; Andrew M Watkins; Paramjit S Arora
Journal:  Acc Chem Res       Date:  2017-05-31       Impact factor: 22.384

10.  X-ray crystallographic structure of an artificial beta-sheet dimer.

Authors:  Omid Khakshoor; Aaron J Lin; Tyler P Korman; Michael R Sawaya; Shiou-Chuan Tsai; David Eisenberg; James S Nowick
Journal:  J Am Chem Soc       Date:  2010-08-25       Impact factor: 15.419
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