BACKGROUND: Acute kidney injury (AKI) is a common complication in many infectious diseases. There are few studies to investigate risk factors for death in infectious diseases-associated AKI. METHODS: This is a retrospective study including all patients with acute kidney injury (AKI) admitted to an infectious diseases intensive care unit (ICU) in Brazil between October 2003 and September 2006. RESULTS: A total of 722 patients were admitted to the infectious disease ICU in the study period. AKI occurred in 147 cases (17.7%). The mean age was 45 +/- 5.6 years, and 77% were male. The mean length of hospital stay was 11.5 +/- 10.3 days. The main causes of ICU hospitalization were acquired immunodeficiency syndrome (AIDS)-related diseases (28 .6%), pneumonia 13%), leptospirosis (11.6%), meningitis (8.2%), disseminated histoplasmosis (6.8%) and tetanus (5.4%). The main cause of AKI was sepsis (41.5%). Patients were classified according to RIFLE as "Risk" (5.6%), "Injury" (21.7%) and "Failure" (72.7%). Patients in "Failure" showed a higher mortality (p = 0.007). Multivariate analysis showed that dependent risk factors for death were oliguria (OR = 5.59, P = 0.002), metabolic acidosis (OR = 5.13, P = 0.01), sepsis (OR = 4.79, P = 0.001), hypovolaemia (OR = 4.11, P = 0.01), use of vasoactive drugs (OR = 3.34, P = 0.02), use of mechanical ventilation (OR = 2.94, P = 0.03) and high APACHE II score (OR = 1.14, P = 0.001). CONCLUSION: There are important risk factors for death among critically ill patients with infectious diseases associated with AKI.
BACKGROUND:Acute kidney injury (AKI) is a common complication in many infectious diseases. There are few studies to investigate risk factors for death in infectious diseases-associated AKI. METHODS: This is a retrospective study including all patients with acute kidney injury (AKI) admitted to an infectious diseases intensive care unit (ICU) in Brazil between October 2003 and September 2006. RESULTS: A total of 722 patients were admitted to the infectious disease ICU in the study period. AKI occurred in 147 cases (17.7%). The mean age was 45 +/- 5.6 years, and 77% were male. The mean length of hospital stay was 11.5 +/- 10.3 days. The main causes of ICU hospitalization were acquired immunodeficiency syndrome (AIDS)-related diseases (28 .6%), pneumonia 13%), leptospirosis (11.6%), meningitis (8.2%), disseminated histoplasmosis (6.8%) and tetanus (5.4%). The main cause of AKI was sepsis (41.5%). Patients were classified according to RIFLE as "Risk" (5.6%), "Injury" (21.7%) and "Failure" (72.7%). Patients in "Failure" showed a higher mortality (p = 0.007). Multivariate analysis showed that dependent risk factors for death were oliguria (OR = 5.59, P = 0.002), metabolic acidosis (OR = 5.13, P = 0.01), sepsis (OR = 4.79, P = 0.001), hypovolaemia (OR = 4.11, P = 0.01), use of vasoactive drugs (OR = 3.34, P = 0.02), use of mechanical ventilation (OR = 2.94, P = 0.03) and high APACHE II score (OR = 1.14, P = 0.001). CONCLUSION: There are important risk factors for death among critically ill patients with infectious diseases associated with AKI.
Authors: Elizabeth F Daher; Geraldo B Silva; Rafael S A Lima; Rosa M S Mota; Hermano A L Rocha; Krasnalhia Lívia S de Abreu; Adller G C Barreto; Eanes D B Pereira; Sônia M H A Araújo; Alexandre B Libório Journal: Am J Trop Med Hyg Date: 2011-09 Impact factor: 2.345
Authors: Kaice A LaFavers; Chadi A Hage; Varun Gaur; Radmila Micanovic; Takashi Hato; Shehnaz Khan; Seth Winfree; Simit Doshi; Ranjani N Moorthi; Homer Twigg; Xue-Ru Wu; Pierre C Dagher; Edward F Srour; Tarek M El-Achkar Journal: Am J Physiol Renal Physiol Date: 2022-06-27
Authors: Krasnalhia Lívia Soares de Abreu; Geraldo Bezerra da Silva Junior; Thalita Diógenes Muniz; Adller Gonçalves Costa Barreto; Rafael Siqueira Athayde Lima; Marcelo Alcântara Holanda; Eanes Delgado Barros Pereira; Alexandre Braga Libório; Elizabeth de Francesco Daher Journal: Rev Bras Ter Intensiva Date: 2013 Apr-Jun