BACKGROUND: Obesity is associated with a chronic and low-grade inflammation which may cause hypoferremia as seen in patients with chronic inflammatory diseases. The aim of the present study was to investigate the relationship between iron status and markers of inflammation in morbidly obese women and the effect of bariatric surgery. METHODS: Our cohort of patients consisted of 178 morbidly obese females selected for bariatric surgery. Clinical and biochemical data were recorded before surgery, and histopathological studies were carried out on preoperative liver biopsy samples. Fifty-five patients have been followed up after bariatric surgery. RESULTS: A high prevalence of iron depletion was present in this cohort, with 53% having a transferrin saturation ratio below 0.20. Iron depletion was significantly correlated with raised levels of indices of inflammation, C-reactive protein (CRP), orosomucoid and haptoglobin), and with the white blood cell count. In multivariate analysis, orosomucoid and CRP were independently associated with iron depletion. Moreover, 6 months after bariatric surgery, inflammation level decreased, which was inversely correlated with the increase in transferrin saturation. CONCLUSIONS: Iron depletion is common in morbidly obese women. Low-grade chronic inflammation associated with obesity could be a modulator of iron uptake and utilization. Bariatric surgery may reduce chronic inflammation and improve iron status.
BACKGROUND:Obesity is associated with a chronic and low-grade inflammation which may cause hypoferremia as seen in patients with chronic inflammatory diseases. The aim of the present study was to investigate the relationship between iron status and markers of inflammation in morbidly obesewomen and the effect of bariatric surgery. METHODS: Our cohort of patients consisted of 178 morbidly obese females selected for bariatric surgery. Clinical and biochemical data were recorded before surgery, and histopathological studies were carried out on preoperative liver biopsy samples. Fifty-five patients have been followed up after bariatric surgery. RESULTS: A high prevalence of iron depletion was present in this cohort, with 53% having a transferrin saturation ratio below 0.20. Iron depletion was significantly correlated with raised levels of indices of inflammation, C-reactive protein (CRP), orosomucoid and haptoglobin), and with the white blood cell count. In multivariate analysis, orosomucoid and CRP were independently associated with iron depletion. Moreover, 6 months after bariatric surgery, inflammation level decreased, which was inversely correlated with the increase in transferrin saturation. CONCLUSIONS:Iron depletion is common in morbidly obesewomen. Low-grade chronic inflammation associated with obesity could be a modulator of iron uptake and utilization. Bariatric surgery may reduce chronic inflammation and improve iron status.
Authors: Elizabeta Nemeth; Erika V Valore; Mary Territo; Gary Schiller; Alan Lichtenstein; Tomas Ganz Journal: Blood Date: 2002-11-14 Impact factor: 22.113
Authors: L B Yanoff; C M Menzie; B Denkinger; N G Sebring; T McHugh; A T Remaley; J A Yanovski Journal: Int J Obes (Lond) Date: 2007-04-17 Impact factor: 5.095
Authors: Cynthia L Ogden; Margaret D Carroll; Lester R Curtin; Margaret A McDowell; Carolyn J Tabak; Katherine M Flegal Journal: JAMA Date: 2006-04-05 Impact factor: 56.272
Authors: D C Nieman; S I Nehlsen-Cannarella; D A Henson; D E Butterworth; O R Fagoaga; B J Warren; M K Rainwater Journal: Int J Obes Relat Metab Disord Date: 1996-04
Authors: John G Kral; Swan N Thung; Simon Biron; Frederic-Simon Hould; Stefane Lebel; Simon Marceau; Serge Simard; Picard Marceau Journal: Surgery Date: 2004-01 Impact factor: 3.982
Authors: C Chiellini; F Santini; A Marsili; P Berti; A Bertacca; C Pelosini; G Scartabelli; E Pardini; J López-Soriano; R Centoni; A M Ciccarone; L Benzi; P Vitti; S Del Prato; A Pinchera; M Maffei Journal: J Clin Endocrinol Metab Date: 2004-06 Impact factor: 5.958
Authors: Anne Sophie Schneck; Rodolphe Anty; Albert Tran; Audrey Hastier; Imed Ben Amor; Jean Gugenheim; Antonio Iannelli; Thierry Piche Journal: Obes Surg Date: 2016-07 Impact factor: 4.129
Authors: Ajay Kumar Jain; Carel W le Roux; Puneet Puri; Ali Tavakkoli; Nana Gletsu-Miller; Blandine Laferrère; Richard Kellermayer; John K DiBaise; Robert G Martindale; Bruce M Wolfe Journal: JPEN J Parenter Enteral Nutr Date: 2018-02 Impact factor: 4.016
Authors: Eva Solá; Ana Jover; Antonio López-Ruiz; María Jarabo; Amparo Vayá; Carlos Morillas; Marcelino Gómez-Balaguer; Antonio Hernández-Mijares Journal: Obes Surg Date: 2008-12-03 Impact factor: 4.129
Authors: Hakeam A Hakeam; Patrick J O'Regan; Abdulrahman M Salem; Fahad Y Bamehriz; Abdelmoneim M Eldali Journal: Obes Surg Date: 2009-07-15 Impact factor: 4.129
Authors: Segundo Á Gómez-Abril; Carlos Morillas-Ariño; Jose L Ponce-Marco; Teresa Torres-Sánchez; Fernando Delgado-Gomis; Antonio Hernández-Mijares; Milagros Rocha Journal: Obes Surg Date: 2016-11 Impact factor: 4.129