Anne Sophie Schneck1,2, Rodolphe Anty3,2, Albert Tran3,2, Audrey Hastier3, Imed Ben Amor1, Jean Gugenheim1,2, Antonio Iannelli1,2, Thierry Piche4,5. 1. Service de Chirurgie Digestive et Transplantation Hépatique, Hôpital Archet 2, Pôle Digestif, CHU Nice, Université de Nice Sophia-Antipolis, Nice, France. 2. INSERM, U1065, Team 8 "Hepatic complications in obesity", C3M, Nice, France. 3. Service d'Hépato-Gastroentérologie et de Cancérologie Digestive, Hôpital Archet 2, Pôle Digestif, CHU de Nice, Université de Nice Sophia-Antipolis, Nice, France. 4. Service d'Hépato-Gastroentérologie et de Cancérologie Digestive, Hôpital Archet 2, Pôle Digestif, CHU de Nice, Université de Nice Sophia-Antipolis, Nice, France. piche.t@chu-nice.fr. 5. Service d'Immunologie, Pôle Biologie, EA 6302 Tolérance Immunitaire, Hôpital Archet 1 Université de Nice Sophia-Antipolis, Nice, France. piche.t@chu-nice.fr.
Abstract
BACKGROUND: Only a few recent reports have suggested a correlation between obesity and irritable bowel syndrome (IBS). We aimed to determine the prevalence and severity of IBS in a prospective cohort of obese patients undergoing bariatric surgery in Nice Hospital (France). METHODS: One hundred obese patients were included prospectively before bariatric surgery. A diagnosis of IBS and each subtype was performed according to Rome-III criteria using a Bristol scale for stool consistency. Patients provided information on IBS-related comorbidities, including chronic fatigue, migraine, lower back pain, gastroesophageal reflux disease (GERD), genitourinary problems, and dyspepsia. Patients completed questionnaires to assess the severity of IBS, GERD, psychological factors (anxiety, depression), fatigue, and quality of life. RESULTS: Thirty patients fulfilled the Rome-III criteria for IBS. There was no difference in age, gender, or BMI between obese patients with or without IBS. Obese patients with IBS reported a significantly higher prevalence of GERD, migraines, lower back pain, genitourinary problems, chronic fatigue, and dyspepsia. Obese patients with IBS had significant higher scores of fatigue, anxiety, depression, and poorer quality of life. Obese patients that had both IBS and GERD had significantly higher IBS severity scores than those without GERD. In a logistic regression model including BMI, anxiety, depression, gender, and GERD score, only anxiety was significantly and independently associated with IBS. CONCLUSIONS: Thirty percent of obese patients had IBS: its severity was not correlated with BMI. However, anxiety was independently associated with IBS, suggesting that psychological factors are key features of IBS, whatever the presence of obesity.
BACKGROUND: Only a few recent reports have suggested a correlation between obesity and irritable bowel syndrome (IBS). We aimed to determine the prevalence and severity of IBS in a prospective cohort of obesepatients undergoing bariatric surgery in Nice Hospital (France). METHODS: One hundred obesepatients were included prospectively before bariatric surgery. A diagnosis of IBS and each subtype was performed according to Rome-III criteria using a Bristol scale for stool consistency. Patients provided information on IBS-related comorbidities, including chronic fatigue, migraine, lower back pain, gastroesophageal reflux disease (GERD), genitourinary problems, and dyspepsia. Patients completed questionnaires to assess the severity of IBS, GERD, psychological factors (anxiety, depression), fatigue, and quality of life. RESULTS: Thirty patients fulfilled the Rome-III criteria for IBS. There was no difference in age, gender, or BMI between obesepatients with or without IBS. Obesepatients with IBS reported a significantly higher prevalence of GERD, migraines, lower back pain, genitourinary problems, chronic fatigue, and dyspepsia. Obesepatients with IBS had significant higher scores of fatigue, anxiety, depression, and poorer quality of life. Obesepatients that had both IBS and GERD had significantly higher IBS severity scores than those without GERD. In a logistic regression model including BMI, anxiety, depression, gender, and GERD score, only anxiety was significantly and independently associated with IBS. CONCLUSIONS: Thirty percent of obesepatients had IBS: its severity was not correlated with BMI. However, anxiety was independently associated with IBS, suggesting that psychological factors are key features of IBS, whatever the presence of obesity.
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