| Literature DB >> 18329063 |
Yuanding Chen1, Yuling Wen, Xiao Liu, Xinyu Xiong, Zhiliang Cao, Qinghuan Zhao, Yang Yu, Xingxiao Yin, Chuanyin Li, Yaochun Fan.
Abstract
A G2P[4]/NSP4[A] rotavirus strain TB-Chen was isolated from a 2-year-old patient hospitalized with acute gastroenteritis in Kunming, China. The strain TB-Chen was demonstrated having group A-specific antigenicity, a "short" (subgroup II) electropherotype. To investigate its overall genomic relatedness and to determine which group it belonged, the complete genome of strain TB-Chen was determined. Genomic comparison based on amino acid sequence identity and phylogenetic analysis revealed that all 11 gene segments of strain TB-Chen were highly identical (>91.80%) with the representative G2P[4]/NSP4[A] human strains DS-1, S2, NR1 and IS2, suggesting that this rotavirus strain was derived from human host. Besides, almost all the available representative rotavirus gene segments among group A were analyzed and identified within 15 G-types, 28 P-types, and 6 NSP4 genotypes. This is the first report of group A rotavirus genomic analyses in China and the findings have important implications for rotavirus vaccine development.Entities:
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Year: 2008 PMID： 18329063 DOI： 10.1016/j.virol.2008.01.003
Source DB: PubMed Journal: Virology ISSN： 0042-6822 Impact factor: 3.616