AIM: To investigate the association between the CTLA-4 promoter-1722(T/C) and 3' untranslated region CT60(G/A) polymorphisms and the risk of breast cancer in Han women of northeast China. METHODS: 328 patients with breast cancer and 327 healthy people as control were genotyped for -1722 and CT60 polymorphism using polymerase chain reaction and restriction fragment length polymorphism. RESULTS: The frequency of the G allele at the CT60 site in breast cancer patients was statistically higher than that in control(28.7% vs 23.5%, P=0.0352, OR=1.30, 95% CI=1.02-1.67). The frequency of -1722C-CT60A haplotype in control was significantly higher than that in breast cancer patients(P=0.0283, OR=0.77, 95% CI=0.97-0.61). However, the distribution of genotypes at -1722 site was not significantly different between breast cancer patients and control. CONCLUSION: The polymorphism of -1722T/C and CT60G/A may be related to the development of breast cancer in Han women of northern China.
AIM: To investigate the association between the CTLA-4 promoter-1722(T/C) and 3' untranslated region CT60(G/A) polymorphisms and the risk of breast cancer in Han women of northeast China. METHODS: 328 patients with breast cancer and 327 healthy people as control were genotyped for -1722 and CT60 polymorphism using polymerase chain reaction and restriction fragment length polymorphism. RESULTS: The frequency of the G allele at the CT60 site in breast cancerpatients was statistically higher than that in control(28.7% vs 23.5%, P=0.0352, OR=1.30, 95% CI=1.02-1.67). The frequency of -1722C-CT60A haplotype in control was significantly higher than that in breast cancerpatients(P=0.0283, OR=0.77, 95% CI=0.97-0.61). However, the distribution of genotypes at -1722 site was not significantly different between breast cancerpatients and control. CONCLUSION: The polymorphism of -1722T/C and CT60G/A may be related to the development of breast cancer in Han women of northern China.