| Literature DB >> 18327912 |
Maoluo Gan1, Yanling Zhang, Sheng Lin, Mingtao Liu, Weixia Song, Jiachen Zi, Yongchun Yang, Xiaona Fan, Jiangong Shi, Jinfeng Hu, Jiandong Sun, Naihong Chen.
Abstract
Seven new neolignan glycosides ( 1- 7), two arylglycerol glycosides ( 8, 9), and 18 known glycosides have been isolated from an ethanolic extract of the root of Iodes cirrhosa. Their structures including absolute configurations were determined by spectroscopic and chemical methods. Based on analysis of the NMR data of threo and erythro 8-4'-oxyneolignans and arylglycerols in different solvents, the validity of J 7,8 and Deltadelta C8-C7 values to distinguish threo and erythro derivatives was discussed. In the in vitro assays, compound 4 and liriodendrin ( 17) both showed activity against glutamate-induced PC12 cell damage at 10 (-5) M.Entities:
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Year: 2008 PMID： 18327912 DOI： 10.1021/np7007329
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050