OBJECTIVE: Longitudinal studies on cohorts of babies enrolled at birth are ongoing in Europe. On the basis of these experiences, a birth cohort study should be implemented in Italy at a national level. A pilot study is ongoing in Rome, from which we report data on adherence at recruitment and follow-up. DESIGN: Prospective cohort study. SETTING: the birth cohort was enrolled between June 2003 and October 2004, in two hospital ofRome in the district ofthe Local Health Unit RME. PARTICIPANTS: we enrolled children of women older than 18 years, Italian citizens and residents in the Local Health Unit RME. MAIN OUTCOME MEASURES: Baseline characteristics of enrolled women were compared with those of refusals, and characteristics of children with a complete follow-up with those lost at follow-up. Prevalence Rate ratio (PR) and the relative 95% confidence interval were calculated. RESULTS: The cohort consisted of 704 women (54% of the contacted) and 719 children. A low level of instruction (PR 2.84), and a caesarean delivery (OR 1.41) were significantly associated with the refusal. After the enrolment 25 children were lost, 117 were partially followed-up and 577 had a complete follow-up until the 15 month visit. Mothers of children lost at follow-up were less instructed (PR 1.69) and smoked during pregnancy (PR 1.57). CONCLUSIONS: During the enrolment and the follow-up of a birth cohort greater efforts must be done to avoid selection for the socioeconomic level of the family. Keeping a high response rate to follow-up is the only way to ensure a good level of internal validity.
OBJECTIVE: Longitudinal studies on cohorts of babies enrolled at birth are ongoing in Europe. On the basis of these experiences, a birth cohort study should be implemented in Italy at a national level. A pilot study is ongoing in Rome, from which we report data on adherence at recruitment and follow-up. DESIGN: Prospective cohort study. SETTING: the birth cohort was enrolled between June 2003 and October 2004, in two hospital ofRome in the district ofthe Local Health Unit RME. PARTICIPANTS: we enrolled children of women older than 18 years, Italian citizens and residents in the Local Health Unit RME. MAIN OUTCOME MEASURES: Baseline characteristics of enrolled women were compared with those of refusals, and characteristics of children with a complete follow-up with those lost at follow-up. Prevalence Rate ratio (PR) and the relative 95% confidence interval were calculated. RESULTS: The cohort consisted of 704 women (54% of the contacted) and 719 children. A low level of instruction (PR 2.84), and a caesarean delivery (OR 1.41) were significantly associated with the refusal. After the enrolment 25 children were lost, 117 were partially followed-up and 577 had a complete follow-up until the 15 month visit. Mothers of children lost at follow-up were less instructed (PR 1.69) and smoked during pregnancy (PR 1.57). CONCLUSIONS: During the enrolment and the follow-up of a birth cohort greater efforts must be done to avoid selection for the socioeconomic level of the family. Keeping a high response rate to follow-up is the only way to ensure a good level of internal validity.
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Authors: Andrea Ranzi; Daniela Porta; Chiara Badaloni; Giulia Cesaroni; Paolo Lauriola; Marina Davoli; Francesco Forastiere Journal: Occup Environ Med Date: 2014-03-21 Impact factor: 4.402
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Authors: Elaina A MacIntyre; Ulrike Gehring; Anna Mölter; Elaine Fuertes; Claudia Klümper; Ursula Krämer; Ulrich Quass; Barbara Hoffmann; Mireia Gascon; Bert Brunekreef; Gerard H Koppelman; Rob Beelen; Gerard Hoek; Matthias Birk; Johan C de Jongste; H A Smit; Josef Cyrys; Olena Gruzieva; Michal Korek; Anna Bergström; Raymond M Agius; Frank de Vocht; Angela Simpson; Daniela Porta; Francesco Forastiere; Chiara Badaloni; Giulia Cesaroni; Ana Esplugues; Ana Fernández-Somoano; Aitana Lerxundi; Jordi Sunyer; Marta Cirach; Mark J Nieuwenhuijsen; Göran Pershagen; Joachim Heinrich Journal: Environ Health Perspect Date: 2013-10-22 Impact factor: 9.031
Authors: J Bousquet; J M Anto; M Akdis; C Auffray; T Keil; I Momas; D S Postma; R Valenta; M Wickman; A Cambon-Thomsen; T Haahtela; B N Lambrecht; K C Lodrup Carlsen; G H Koppelman; J Sunyer; T Zuberbier; I Annesi-Maesano; A Arno; C Bindslev-Jensen; G De Carlo; F Forastiere; J Heinrich; M L Kowalski; D Maier; E Melén; S Palkonen; H A Smit; M Standl; J Wright; A Asarnoj; M Benet; N Ballardini; J Garcia-Aymerich; U Gehring; S Guerra; C Hohman; I Kull; C Lupinek; M Pinart; I Skrindo; M Westman; D Smagghe; C Akdis; R Albang; V Anastasova; N Anderson; C Bachert; S Ballereau; F Ballester; X Basagana; A Bedbrook; A Bergstrom; A von Berg; B Brunekreef; E Burte; K H Carlsen; L Chatzi; J M Coquet; M Curin; P Demoly; E Eller; M P Fantini; B Gerhard; H Hammad; L von Hertzen; V Hovland; B Jacquemin; J Just; T Keller; M Kerkhof; R Kiss; M Kogevinas; S Koletzko; S Lau; I Lehmann; N Lemonnier; R McEachan; M Mäkelä; J Mestres; E Minina; P Mowinckel; R Nadif; M Nawijn; S Oddie; J Pellet; I Pin; D Porta; F Rancière; A Rial-Sebbag; Y Saeys; M J Schuijs; V Siroux; C G Tischer; M Torrent; R Varraso; J De Vocht; K Wenger; S Wieser; C Xu Journal: Allergy Date: 2016-08-23 Impact factor: 13.146