Literature DB >> 18324715

N-myristoyltransferase: a prospective drug target for protozoan parasites.

Paul W Bowyer1, Edward W Tate, Robin J Leatherbarrow, Anthony A Holder, Deborah F Smith, Katherine A Brown.   

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Year:  2008        PMID： 18324715     DOI： 10.1002/cmdc.200700301

Source DB:  PubMed          Journal:  ChemMedChem        ISSN： 1860-7179            Impact factor:   3.466


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  26 in total

1.  Homology modeling and molecular dynamics simulation of N-myristoyltransferase from protozoan parasites: active site characterization and insights into rational inhibitor design.

Authors:  Chunquan Sheng; Haitao Ji; Zhenyuan Miao; Xiaoyin Che; Jianzhong Yao; Wenya Wang; Guoqiang Dong; Wei Guo; Jiaguo Lü; Wannian Zhang
Journal:  J Comput Aided Mol Des       Date:  2009-04-16       Impact factor: 3.686

Review 2.  Recent developments in drug discovery for leishmaniasis and human African trypanosomiasis.

Authors:  Advait S Nagle; Shilpi Khare; Arun Babu Kumar; Frantisek Supek; Andriy Buchynskyy; Casey J N Mathison; Naveen Kumar Chennamaneni; Nagendar Pendem; Frederick S Buckner; Michael H Gelb; Valentina Molteni
Journal:  Chem Rev       Date:  2014-11-03       Impact factor: 60.622

3.  A new, robust, and nonradioactive approach for exploring N-myristoylation.

Authors:  Francesca Rampoldi; Roger Sandhoff; Robert W Owen; Hermann-Josef Gröne; Stefan Porubsky
Journal:  J Lipid Res       Date:  2012-07-24       Impact factor: 5.922

Review 4.  The chemical toolbox for monitoring protein fatty acylation and prenylation.

Authors:  Rami N Hannoush; Jinglucy Sun
Journal:  Nat Chem Biol       Date:  2010-07       Impact factor: 15.040

Review 5.  State of the art in African trypanosome drug discovery.

Authors:  Robert T Jacobs; Bakela Nare; Margaret A Phillips
Journal:  Curr Top Med Chem       Date:  2011       Impact factor: 3.295

6.  N-myristoyltransferase inhibitors as new leads to treat sleeping sickness.

Authors:  Julie A Frearson; Stephen Brand; Stuart P McElroy; Laura A T Cleghorn; Ondrej Smid; Laste Stojanovski; Helen P Price; M Lucia S Guther; Leah S Torrie; David A Robinson; Irene Hallyburton; Chidochangu P Mpamhanga; James A Brannigan; Anthony J Wilkinson; Michael Hodgkinson; Raymond Hui; Wei Qiu; Olawale G Raimi; Daan M F van Aalten; Ruth Brenk; Ian H Gilbert; Kevin D Read; Alan H Fairlamb; Michael A J Ferguson; Deborah F Smith; Paul G Wyatt
Journal:  Nature       Date:  2010-04-01       Impact factor: 49.962

7.  Protein myristoylation in health and disease.

Authors:  Megan H Wright; William P Heal; David J Mann; Edward W Tate
Journal:  J Chem Biol       Date:  2009-11-07

8.  A fluorescence-based assay for N-myristoyltransferase activity.

Authors:  Victor Goncalves; James A Brannigan; Emmanuelle Thinon; Tayo O Olaleye; Remigiusz Serwa; Salvatore Lanzarone; Anthony J Wilkinson; Edward W Tate; Robin J Leatherbarrow
Journal:  Anal Biochem       Date:  2011-10-14       Impact factor: 3.365

9.  Discovery of Plasmodium vivax N-myristoyltransferase inhibitors: screening, synthesis, and structural characterization of their binding mode.

Authors:  Victor Goncalves; James A Brannigan; David Whalley; Keith H Ansell; Barbara Saxty; Anthony A Holder; Anthony J Wilkinson; Edward W Tate; Robin J Leatherbarrow
Journal:  J Med Chem       Date:  2012-04-03       Impact factor: 7.446

10.  Design and synthesis of inhibitors of Plasmodium falciparum N-myristoyltransferase, a promising target for antimalarial drug discovery.

Authors:  Zhiyong Yu; James A Brannigan; David K Moss; A Marek Brzozowski; Anthony J Wilkinson; Anthony A Holder; Edward W Tate; Robin J Leatherbarrow
Journal:  J Med Chem       Date:  2012-10-15       Impact factor: 7.446
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