AIM: To investigate the relationship between loss of heterozygosity (LOH) for mannose 6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) and the outcomes for primary HCC patients treated with partial hepatectomy. METHODS: The LOH for M6P/IGF2R in primary HCC patients was assessed using six different gene-specific nucleotide polymorphisms. The patients studied were enrolled to undergo partial hepatectomy. RESULTS: M6P/IGF2R was found to be polymorphic in 73.3% (22/30) of the patients, and of these patients, 50.0% (11/22) had tumors showing LOH in M6P/IGF2R. Loss of heterozygosity in M6P/IGF2R was associated with significant reductions in the two year overall survival rate (24.9% vs 65.5%; P=0.04) and the disease-free survival rate (17.8% vs 59.3%; P=0.03). CONCLUSION: These results show M6P/IGF2R LOH predicts poor clinical outcomes in surgically resected primary HCC patients.
AIM: To investigate the relationship between loss of heterozygosity (LOH) for mannose 6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) and the outcomes for primary HCC patients treated with partial hepatectomy. METHODS: The LOH for M6P/IGF2R in primary HCC patients was assessed using six different gene-specific nucleotide polymorphisms. The patients studied were enrolled to undergo partial hepatectomy. RESULTS:M6P/IGF2R was found to be polymorphic in 73.3% (22/30) of the patients, and of these patients, 50.0% (11/22) had tumors showing LOH in M6P/IGF2R. Loss of heterozygosity in M6P/IGF2R was associated with significant reductions in the two year overall survival rate (24.9% vs 65.5%; P=0.04) and the disease-free survival rate (17.8% vs 59.3%; P=0.03). CONCLUSION: These results show M6P/IGF2R LOH predicts poor clinical outcomes in surgically resected primary HCC patients.
Authors: L E Young; K Fernandes; T G McEvoy; S C Butterwith; C G Gutierrez; C Carolan; P J Broadbent; J J Robinson; I Wilmut; K D Sinclair Journal: Nat Genet Date: 2001-02 Impact factor: 38.330
Authors: B Motyka; G Korbutt; M J Pinkoski; J A Heibein; A Caputo; M Hobman; M Barry; I Shostak; T Sawchuk; C F Holmes; J Gauldie; R C Bleackley Journal: Cell Date: 2000-10-27 Impact factor: 41.582
Authors: Yeonhwa Song; Jin-Sun Kim; Se-Hyuk Kim; Yoon Kyung Park; Eunsil Yu; Ki-Hun Kim; Eul-Ju Seo; Heung-Bum Oh; Han Chu Lee; Kang Mo Kim; Haeng Ran Seo Journal: J Exp Clin Cancer Res Date: 2018-05-25