| Literature DB >> 11175780 |
L E Young1, K Fernandes, T G McEvoy, S C Butterwith, C G Gutierrez, C Carolan, P J Broadbent, J J Robinson, I Wilmut, K D Sinclair.
Abstract
Manipulation or non-physiological embryo culture environments can lead to defective fetal programming in livestock. Our demonstration of reduced fetal methylation and expression of ovine IGF2R suggests pre-implantation embryo procedures may be vulnerable to epigenetic alterations in imprinted genes. This highlights the potential benefits of epigenetic diagnostic screening in developing embryo procedures.Entities:
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Year: 2001 PMID： 11175780 DOI： 10.1038/84769
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330