BACKGROUND: Laparoscopic pancreatic surgery is rapidly evolving due to improving instrumentation and surgical techniques. The challenges confronting laparoscopic pancreaticoduodenectomy (LPD), however, are its technical difficulty and its appropriateness for oncologic treatment. This study sought to develop a novel technique for LPD in an acute porcine model and to evaluate the safety and feasibility of LPD before clinical trials are undertaken. METHODS: The LPD procedure was performed in 10 pigs. Modified Child's reconstruction was performed intracorporeally. After the animals were killed, anastomotic sites were investigated by laparotomy. RESULTS: All the animals underwent LPD. The median operation time was 5 h, with minimal blood loss. One choledochojejunostomy had a small leak. CONCLUSIONS: The study proved LPD to be technically safe and feasible in an acute porcine model. Further studies and technical advances are necessary for transition of this clinical application of LPD to humans.
BACKGROUND: Laparoscopic pancreatic surgery is rapidly evolving due to improving instrumentation and surgical techniques. The challenges confronting laparoscopic pancreaticoduodenectomy (LPD), however, are its technical difficulty and its appropriateness for oncologic treatment. This study sought to develop a novel technique for LPD in an acute porcine model and to evaluate the safety and feasibility of LPD before clinical trials are undertaken. METHODS: The LPD procedure was performed in 10 pigs. Modified Child's reconstruction was performed intracorporeally. After the animals were killed, anastomotic sites were investigated by laparotomy. RESULTS: All the animals underwent LPD. The median operation time was 5 h, with minimal blood loss. One choledochojejunostomy had a small leak. CONCLUSIONS: The study proved LPD to be technically safe and feasible in an acute porcine model. Further studies and technical advances are necessary for transition of this clinical application of LPD to humans.
Authors: Heidi Nelson; Daniel J Sargent; H Sam Wieand; James Fleshman; Mehran Anvari; Steven J Stryker; Robert W Beart; Michael Hellinger; Richard Flanagan; Walter Peters; David Ota Journal: N Engl J Med Date: 2004-05-13 Impact factor: 91.245
Authors: Erin H Baker; Samuel W Ross; Ramanathan Seshadri; Ryan Z Swan; David A Iannitti; Dionisios Vrochides; John B Martinie Journal: J Gastrointest Oncol Date: 2015-08