OBJECTIVE: The aim of this study was to investigate the effects of strontium ranelate on insulin like growth factor-1 (IGF-1), leptin and osteocalcin levels in osteoporotic post-menopausal women. STUDY DESIGN: Thirty-three women were given 2 g/day strontium ranelate for 6 months. Serum IGF-1, leptin and osteocalcin levels were measured before and after the treatment. RESULTS: Strontium ranelate treatment increased IGF-1 levels significantly (P = 0.02). Leptin and osteocalcin levels did not change significantly before and after the treatment. There was no correlation between basal and 6-months treatment levels of IGF-1 and leptin. CONCLUSION: Strontium ranelate increases serum IGF-1 levels in osteoporotic post-menopausal women.
OBJECTIVE: The aim of this study was to investigate the effects of strontium ranelate on insulin like growth factor-1 (IGF-1), leptin and osteocalcin levels in osteoporotic post-menopausal women. STUDY DESIGN: Thirty-three women were given 2 g/day strontium ranelate for 6 months. Serum IGF-1, leptin and osteocalcin levels were measured before and after the treatment. RESULTS:Strontium ranelate treatment increased IGF-1 levels significantly (P = 0.02). Leptin and osteocalcin levels did not change significantly before and after the treatment. There was no correlation between basal and 6-months treatment levels of IGF-1 and leptin. CONCLUSION:Strontium ranelate increases serum IGF-1 levels in osteoporotic post-menopausal women.
Authors: Jean-Yves Reginster; Janusz Badurski; Nicholas Bellamy; William Bensen; Roland Chapurlat; Xavier Chevalier; Claus Christiansen; Harry Genant; Federico Navarro; Evgeny Nasonov; Philip N Sambrook; Timothy D Spector; Cyrus Cooper Journal: Ann Rheum Dis Date: 2012-11-01 Impact factor: 19.103
Authors: Gema Barrientos; Javier Alves; Víctor Toro; María Concepción Robles; Diego Muñoz; Marcos Maynar Journal: Int J Environ Res Public Health Date: 2020-09-09 Impact factor: 3.390