AIMS: To compare the postprandial lipid responses in subjects with prediabetes (IFG and IGT), newly detected diabetes mellitus (NDDM) and normal glucose tolerance (NGT). METHODS: Postprandial lipid responses to a standard oral fat challenge was studied in forty-four subjects who were divided after an OGTT into NGT, pure impaired fasting glucose (PIFG), pure impaired glucose tolerance (PIGT) and NDDM. RESULTS: There was a significantly higher postprandial triglyceride (PPTg) response with a higher PPTg area under curve (p=0.004) and peak PPTg levels (p=0.003) in patients with NDDM but not with either PIFG (p>0.05) or PIGT (p>0.05) when compared with NGT. Overall, PPTg responses correlated significantly with fasting plasma glucose (p=0.001) and 2h plasma glucose (p=0.001) but not with age, sex, body mass index, waist, or insulin resistance. CONCLUSION: Subjects with newly detected diabetes mellitus displayed postprandial hypertriglyceridemia after a standard oral fat meal challenge while no such abnormality could be demonstrated in subjects with IFG or IGT. This defect is probably related to glycemic status and insulin resistance.
AIMS: To compare the postprandial lipid responses in subjects with prediabetes (IFG and IGT), newly detected diabetes mellitus (NDDM) and normal glucose tolerance (NGT). METHODS: Postprandial lipid responses to a standard oral fat challenge was studied in forty-four subjects who were divided after an OGTT into NGT, pure impaired fasting glucose (PIFG), pure impaired glucose tolerance (PIGT) and NDDM. RESULTS: There was a significantly higher postprandial triglyceride (PPTg) response with a higher PPTg area under curve (p=0.004) and peak PPTg levels (p=0.003) in patients with NDDM but not with either PIFG (p>0.05) or PIGT (p>0.05) when compared with NGT. Overall, PPTg responses correlated significantly with fasting plasma glucose (p=0.001) and 2h plasma glucose (p=0.001) but not with age, sex, body mass index, waist, or insulin resistance. CONCLUSION: Subjects with newly detected diabetes mellitus displayed postprandial hypertriglyceridemia after a standard oral fat meal challenge while no such abnormality could be demonstrated in subjects with IFG or IGT. This defect is probably related to glycemic status and insulin resistance.
Authors: Johanna H M Stroeve; Herman van Wietmarschen; Bas H A Kremer; Ben van Ommen; Suzan Wopereis Journal: Genes Nutr Date: 2015-04-21 Impact factor: 5.523
Authors: Montosh Chakraborty; Prerna Singh; Jyothi M P Dsouza; Karthikeyan Pethusamy; Pandurang V Thatkar Journal: J Family Med Prim Care Date: 2020-01-28