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Literature DB >> 18316523

Differential effects of quinoline antimalarials on endocytosis in Plasmodium falciparum.

Lindi Roberts¹, Timothy J Egan, Keith A Joiner, Heinrich C Hoppe.

Abstract

The effects of quinoline antimalarials on endocytosis by Plasmodium falciparum was investigated by measuring parasite hemoglobin levels, peroxidase uptake, and transport vesicle content. Mefloquine, quinine, and halofantrine inhibited endocytosis, and chloroquine inhibited vesicle trafficking, while amodiaquine shared both effects. Protease inhibitors moderated hemoglobin perturbations, suggesting a common role for heme binding.

Entities: Chemical Species

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Year: 2008 PMID： 18316523 PMCID： PMC2346632 DOI： 10.1128/AAC.01478-07

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

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6. PfPI3K, a phosphatidylinositol-3 kinase from Plasmodium falciparum, is exported to the host erythrocyte and is involved in hemoglobin trafficking.

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9. Large-scale differential proteome analysis in Plasmodium falciparum under drug treatment.

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10. Identification of inhibitors of Plasmodium falciparum phosphoethanolamine methyltransferase using an enzyme-coupled transmethylation assay.

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