Literature DB >> 1831355

Diabetes-induced decrease in the mRNA coding for sarcoplasmic reticulum Ca(2+)-ATPase in adult rat cardiomyocytes.

M Russ1, H Reinauer, J Eckel.   

Abstract

The present study examined the level of the mRNA coding for the sarcoplasmic reticulum (SR) Ca(2+)-ATPase in isolated ventricular myocytes from streptozotocin-diabetic rats and genetically obese (fa/fa) rats using Northern blotting techniques. In both animal models one single transcript with a mean size of 4.12 kb could be detected. In insulin-deficient rats the Ca(2+)-ATPase transcript level decreased by 51% when compared to normal rats. In obese animals a modest decrease in the Ca(2+)-ATPase mRNA content to 77% of lean controls has been detected. Decreased mRNA expression of the SR Ca(2+)-ATPase may partly explain the delayed diastolic relaxation observed in the diabetic heart.

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Year:  1991        PMID： 1831355     DOI： 10.1016/0006-291x(91)90977-f

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  8 in total

1.  Impaired mitochondrial energy supply coupled to increased H2O2 emission under energy/redox stress leads to myocardial dysfunction during Type I diabetes.

Authors:  Carlo G Tocchetti; Brian A Stanley; Vidhya Sivakumaran; Djahida Bedja; Brian O'Rourke; Nazareno Paolocci; Sonia Cortassa; Miguel A Aon
Journal:  Clin Sci (Lond)       Date:  2015-06-11       Impact factor: 6.124

2.  Changes in the expression of Na+/K+-ATPase isoenzymes in the left ventricle of diabetic rat hearts: effect of insulin treatment.

Authors:  A Vér; I Szántó; T Bányász; P Csermely; E Végh; J Somogyi
Journal:  Diabetologia       Date:  1997-11       Impact factor: 10.122

3.  Differential changes in cardiac myofibrillar and sarcoplasmic reticular gene expression in alloxan-induced diabetes.

Authors:  L Golfman; I M Dixon; N Takeda; D Chapman; N S Dhalla
Journal:  Mol Cell Biochem       Date:  1999-10       Impact factor: 3.396

Review 4.  Altered cardiac calcium handling in diabetes.

Authors:  Darrell D Belke; Wolfgang H Dillmann
Journal:  Curr Hypertens Rep       Date:  2004-12       Impact factor: 5.369

5.  Modification of myosin isozymes and SR Ca(2+)-pump ATPase of the diabetic rat heart by lipid-lowering interventions.

Authors:  H Rupp; V Elimban; N S Dhalla
Journal:  Mol Cell Biochem       Date:  1994-03-16       Impact factor: 3.396

6.  Chronic diabetes alters function and expression of ryanodine receptor calcium-release channels in rat hearts.

Authors:  Keshore R Bidasee; Karuna Nallani; Bruce Henry; U Deniz Dincer; Henry R Besch
Journal:  Mol Cell Biochem       Date:  2003-07       Impact factor: 3.396

Review 7.  Insulin Receptors and Insulin Action in the Heart: The Effects of Left Ventricular Assist Devices.

Authors:  Konstantina Pantazi; Eleni Karlafti; Alexandra Bekiaridou; Matthaios Didagelos; Antonios Ziakas; Triantafyllos Didangelos
Journal:  Biomolecules       Date:  2022-04-14

8.  Dysregulation of the calcium handling protein, CCDC47, is associated with diabetic cardiomyopathy.

Authors:  Khampaseuth Thapa; Kai Connie Wu; Aishwarya Sarma; Eric M Grund; Angela Szeto; Armando J Mendez; Stephane Gesta; Vivek K Vishnudas; Niven R Narain; Rangaprasad Sarangarajan
Journal:  Cell Biosci       Date:  2018-08-17       Impact factor: 7.133
  8 in total

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