Literature DB >> 15527685

Altered cardiac calcium handling in diabetes.

Darrell D Belke1, Wolfgang H Dillmann.   

Abstract

Diabetes results in a cardiomyopathy characterized by reduced contractility that is primarily the result of changes in calcium handling within the myocyte. Because most of the calcium involved in excitation-contraction (EC) coupling is derived from the sarcoplasmic reticulum (SR), it is no surprise that many studies have found a reduction in sarco-endoplasmic reticulum calcium ATPase (SERCA) activity in the diabetic state. In this review, we outline the changes to SR calcium handling in the diabetic state and, through the use of transgenic mice and adenoviral gene therapy, we examine how SR function can be improved by the expression of various proteins that are directly and indirectly involved in calcium handling. Improving SERCA activity plays an important role in ameliorating the contractile phenotype associated with the diabetic state.

Entities:  

Mesh：

Substances：

Year:  2004        PMID： 15527685     DOI： 10.1007/s11906-004-0035-3

Source DB:  PubMed          Journal:  Curr Hypertens Rep        ISSN： 1522-6417            Impact factor:   5.369


  52 in total

Review 1.  Catecholamines, cardiac beta-adrenergic receptors, and heart failure.

Authors:  R J Lefkowitz; H A Rockman; W J Koch
Journal:  Circulation       Date:  2000-04-11       Impact factor: 29.690

2.  Superinhibition of sarcoplasmic reticulum function by phospholamban induces cardiac contractile failure.

Authors:  K Haghighi; A G Schmidt; B D Hoit; A G Brittsan; A Yatani; J W Lester; J Zhai; Y Kimura; G W Dorn; D H MacLennan; E G Kranias
Journal:  J Biol Chem       Date:  2001-04-27       Impact factor: 5.157

3.  Elevated nucleocytoplasmic glycosylation by O-GlcNAc results in insulin resistance associated with defects in Akt activation in 3T3-L1 adipocytes.

Authors:  Keith Vosseller; Lance Wells; M Daniel Lane; Gerald W Hart
Journal:  Proc Natl Acad Sci U S A       Date:  2002-04-16       Impact factor: 11.205

4.  Calcium sparks and excitation-contraction coupling in phospholamban-deficient mouse ventricular myocytes.

Authors:  L F Santana; E G Kranias; W J Lederer
Journal:  J Physiol       Date:  1997-08-15       Impact factor: 5.182

5.  Association of sorcin with the cardiac ryanodine receptor.

Authors:  M B Meyers; V M Pickel; S S Sheu; V K Sharma; K W Scotto; G I Fishman
Journal:  J Biol Chem       Date:  1995-11-03       Impact factor: 5.157

6.  Transgenic overexpression of the sarcoplasmic reticulum Ca2+ATPase improves reticular Ca2+ handling in normal and diabetic rat hearts.

Authors:  Roland Vetter; Uwe Rehfeld; Christoph Reissfelder; Wolfgang Weiss; Kay-Dietrich Wagner; Joachim Günther; Annette Hammes; Carsten Tschöpe; Wolfgang Dillmann; Martin Paul
Journal:  FASEB J       Date:  2002-08-21       Impact factor: 5.191

7.  Multiple Sp1 binding sites in the cardiac/slow twitch muscle sarcoplasmic reticulum Ca2+-ATPase gene promoter are required for expression in Sol8 muscle cells.

Authors:  D L Baker; V Dave; T Reed; M Periasamy
Journal:  J Biol Chem       Date:  1996-03-08       Impact factor: 5.157

8.  Diabetes and the accompanying hyperglycemia impairs cardiomyocyte calcium cycling through increased nuclear O-GlcNAcylation.

Authors:  Raymond J Clark; Patrick M McDonough; Eric Swanson; Susanne U Trost; Misa Suzuki; Minoru Fukuda; Wolfgang H Dillmann
Journal:  J Biol Chem       Date:  2003-08-26       Impact factor: 5.157

9.  Sorcin regulates excitation-contraction coupling in the heart.

Authors:  Marian B Meyers; Avi Fischer; Yan-Jie Sun; Coeli M B Lopes; Tibor Rohacs; Tomoe Y Nakamura; Ying-Ying Zhou; Paul C Lee; Ruth A Altschuld; Sylvia A McCune; William A Coetzee; Glenn I Fishman
Journal:  J Biol Chem       Date:  2003-05-16       Impact factor: 5.157

10.  Age-dependent changes in metabolism, contractile function, and ischemic sensitivity in hearts from db/db mice.

Authors:  Ellen Aasum; Anne D Hafstad; David L Severson; Terje S Larsen
Journal:  Diabetes       Date:  2003-02       Impact factor: 9.461
View more
  35 in total

Review 1.  Determinants of frequency-dependent contraction and relaxation of mammalian myocardium.

Authors:  Paul M L Janssen; Muthu Periasamy
Journal:  J Mol Cell Cardiol       Date:  2007-08-28       Impact factor: 5.000

2.  Cardiomyocyte contractile status is associated with differences in fibronectin and integrin interactions.

Authors:  Xin Wu; Zhe Sun; Andrea Foskett; Jerome P Trzeciakowski; Gerald A Meininger; Mariappan Muthuchamy
Journal:  Am J Physiol Heart Circ Physiol       Date:  2010-04-09       Impact factor: 4.733

3.  Diabetes-related defects in sarcoplasmic Ca2+ release are prevented by inactivation of G(alpha)11 and G(alpha)q in murine cardiomyocytes.

Authors:  Dieter Paul Hoyer; Sabine Grönke; Konrad F Frank; Klaus Addicks; Nina Wettschureck; Stefan Offermanns; Erland Erdmann; Hannes Reuter
Journal:  Mol Cell Biochem       Date:  2010-04-07       Impact factor: 3.396

4.  Ablation of phospholamban and sarcolipin results in cardiac hypertrophy and decreased cardiac contractility.

Authors:  Mayilvahanan Shanmugam; Shumin Gao; Chull Hong; Nadezhda Fefelova; Martha C Nowycky; Lai-Hua Xie; Muthu Periasamy; Gopal J Babu
Journal:  Cardiovasc Res       Date:  2010-09-10       Impact factor: 10.787

5.  Mechanisms of impaired calcium handling underlying subclinical diastolic dysfunction in diabetes.

Authors:  Véronique A Lacombe; Serge Viatchenko-Karpinski; Dmitry Terentyev; Arun Sridhar; Sitaramesh Emani; John D Bonagura; David S Feldman; Sandor Györke; Cynthia A Carnes
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2007-08-29       Impact factor: 3.619

Review 6.  Matrix revisited: mechanisms linking energy substrate metabolism to the function of the heart.

Authors:  Andrew N Carley; Heinrich Taegtmeyer; E Douglas Lewandowski
Journal:  Circ Res       Date:  2014-02-14       Impact factor: 17.367

7.  Morphological characteristics of cardiac calcium release units in animals with metabolic and circulatory disorders.

Authors:  Kelly F McGrath; Atsumu Yuki; Yasutaka Manaka; Hiroyuki Tamaki; Kazuto Saito; Hiroaki Takekura
Journal:  J Muscle Res Cell Motil       Date:  2009-11-19       Impact factor: 2.698

8.  Malondialdehyde and 4-hydroxynonenal adducts are not formed on cardiac ryanodine receptor (RyR2) and sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA2) in diabetes.

Authors:  Caronda J Moore; Chun Hong Shao; Ryoji Nagai; Shelby Kutty; Jaipaul Singh; Keshore R Bidasee
Journal:  Mol Cell Biochem       Date:  2013-01-25       Impact factor: 3.396

9.  Conditional increase in SERCA2a protein is able to reverse contractile dysfunction and abnormal calcium flux in established diabetic cardiomyopathy.

Authors:  Jorge Suarez; Brian Scott; Wolfgang H Dillmann
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2008-09-17       Impact factor: 3.619

10.  Cysteine-674 oxidation and degradation of sarcoplasmic reticulum Ca(2+) ATPase in diabetic pig aorta.

Authors:  Jia Ying; Victor Sharov; Shanqin Xu; Bingbing Jiang; Ross Gerrity; Christian Schöneich; Richard A Cohen
Journal:  Free Radic Biol Med       Date:  2008-06-13       Impact factor: 7.376
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.