OBJECTIVE: Helicobacter pylori (HP) gastric infection has been implicated as an important factor in occlusive arterial pathology. Nowadays, it is suspected that central serous chorioretinopathy (CSC) is due to a multifocal vascular occlusive disease of the choriocapillaris. The aim of this study was to determine the relation between gastric HP infection and CSC. MATERIALS AND METHODS: We evaluated a group of 16 patients with CSC and 20 controls. HP infection was assessed by the 13C-urea breath test (UBT). Clinical CSC diagnosis was confirmed by fundus biomicroscopy and fluorescein angiography. RESULTS: Out of 16 patients with CSC, 11 (68.75%) were males and 5 (31.25%) females, with a mean age of 46.3 years. HP infection was positive in 11 patients (68.75%) and negative in 5 (31.25%). Men were HP-positive (HP+) in 72.7% of cases, compared to women who were HP+ in 60% of cases. The difference in prevalence of HP between the CSC-group (68.75%) and the control-group (30%) was found to be statistically significant (p< 0.05). HP+ patients had more gastric pain than HP negative (HP-) patients (72.73% vs 20%). CONCLUSIONS: These results indicate a possible statistical association between Helicobacter pylori gastric infection and CSC. HP should thus be considered a risk factor in CSC patients.
OBJECTIVE:Helicobacter pylori (HP) gastric infection has been implicated as an important factor in occlusive arterial pathology. Nowadays, it is suspected that central serous chorioretinopathy (CSC) is due to a multifocal vascular occlusive disease of the choriocapillaris. The aim of this study was to determine the relation between gastric HP infection and CSC. MATERIALS AND METHODS: We evaluated a group of 16 patients with CSC and 20 controls. HP infection was assessed by the 13C-urea breath test (UBT). Clinical CSC diagnosis was confirmed by fundus biomicroscopy and fluorescein angiography. RESULTS: Out of 16 patients with CSC, 11 (68.75%) were males and 5 (31.25%) females, with a mean age of 46.3 years. HP infection was positive in 11 patients (68.75%) and negative in 5 (31.25%). Men were HP-positive (HP+) in 72.7% of cases, compared to women who were HP+ in 60% of cases. The difference in prevalence of HP between the CSC-group (68.75%) and the control-group (30%) was found to be statistically significant (p< 0.05). HP+ patients had more gastric pain than HP negative (HP-) patients (72.73% vs 20%). CONCLUSIONS: These results indicate a possible statistical association between Helicobacter pylori gastric infection and CSC. HP should thus be considered a risk factor in CSC patients.
Authors: Mehmet Erol Can; Fatma Efe Kaplan; Mehmet Murat Uzel; Hasan Kiziltoprak; Mustafa Cagri Ergun; Mustafa Koc; Gülcin Simsek Journal: Int Ophthalmol Date: 2017-08-05 Impact factor: 2.031