| Literature DB >> 18311295 |
Anand T N Kumar1, Scott B Raymond, Brian J Bacskai, David A Boas.
Abstract
We compare frequency-and time-domain formulations of deep-tissue fluorescence imaging of turbid media. Simulations are used to show that time-domain fluorescence tomography, implemented via the asymptotic lifetime-based approach, offers a significantly better separability of multiple lifetime targets than a frequency-domain approach. We also demonstrate experimentally, using complex-shaped phantoms, the advantages of the asymptotic time-domain approach over a Fourier-based approach for analyzing time-domain fluorescence data.Mesh:
Year: 2008 PMID: 18311295 PMCID: PMC2913597 DOI: 10.1364/ol.33.000470
Source DB: PubMed Journal: Opt Lett ISSN: 0146-9592 Impact factor: 3.776