Literature DB >> 1830861

Human platelet basic protein/connective tissue activating peptide-III maps in a gene cluster on chromosome 4q12-q13 along with other genes of the beta-thromboglobulin superfamily.

R H Wenger1, H Hameister, K J Clemetson.   

Abstract

Pro-platelet basic protein (pro-PBP) is the precursor of the two platelet alpha-granule proteins, PBP and connective tissue activating peptide-III. Upon platelet activations they are released and further processed in plasma to beta-thromboglobulin and neutrophil-activating peptide-2. The gene encoding pro-PBP is mapped in this study to chromosome 4q12-q13. At least four other members of this family of small inducible cytokines, including NAP-1/Il-8 and platelet factor 4, reside within the same locus, indicating a gene cluster for the beta-thromboglobulin family.

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Year:  1991        PMID: 1830861     DOI: 10.1007/bf00200921

Source DB:  PubMed          Journal:  Hum Genet        ISSN: 0340-6717            Impact factor:   4.132


  12 in total

1.  Localization of the active type I DNA topoisomerase gene on human chromosome 20q11.2-13.1, and two pseudogenes on chromosomes 1q23-24 and 22q11.2-13.1.

Authors:  N Kunze; G C Yang; Z Y Jiang; H Hameister; S Adolph; K H Wiedorn; A Richter; R Knippers
Journal:  Hum Genet       Date:  1989-12       Impact factor: 4.132

2.  Cloning of cDNA coding for connective tissue activating peptide III from a human platelet-derived lambda gt11 expression library.

Authors:  R H Wenger; A N Wicki; A Walz; N Kieffer; K J Clemetson
Journal:  Blood       Date:  1989-05-01       Impact factor: 22.113

3.  Platelet-derived growth factor-inducible gene JE is a member of a family of small inducible genes related to platelet factor 4.

Authors:  R S Kawahara; T F Deuel
Journal:  J Biol Chem       Date:  1989-01-15       Impact factor: 5.157

Review 4.  Human monocyte chemoattractant protein-1 (MCP-1).

Authors:  E J Leonard; T Yoshimura
Journal:  Immunol Today       Date:  1990-03

5.  Human platelet factor 4 gene is mapped to 4q12----q21.

Authors:  C A Griffin; B S Emanuel; P LaRocco; E Schwartz; M Poncz
Journal:  Cytogenet Cell Genet       Date:  1987

6.  Structural and biological characteristics of connective tissue activating peptide (CTAP-III), a major human platelet-derived growth factor.

Authors:  C W Castor; J W Miller; D A Walz
Journal:  Proc Natl Acad Sci U S A       Date:  1983-02       Impact factor: 11.205

7.  Complete covalent structure of human beta-thromboglobulin.

Authors:  G S Begg; D S Pepper; C N Chesterman; F J Morgan
Journal:  Biochemistry       Date:  1978-05-02       Impact factor: 3.162

8.  Monocyte-derived neutrophil chemotactic factor (MDNCF/IL-8) resides in a gene cluster along with several other members of the platelet factor 4 gene superfamily.

Authors:  W S Modi; M Dean; H N Seuanez; N Mukaida; K Matsushima; S J O'Brien
Journal:  Hum Genet       Date:  1990-01       Impact factor: 4.132

9.  Generation of the neutrophil-activating peptide NAP-2 from platelet basic protein or connective tissue-activating peptide III through monocyte proteases.

Authors:  A Walz; M Baggiolini
Journal:  J Exp Med       Date:  1990-02-01       Impact factor: 14.307

10.  Chemotactic activity of platelet alpha granule proteins for fibroblasts.

Authors:  R M Senior; G L Griffin; J S Huang; D A Walz; T F Deuel
Journal:  J Cell Biol       Date:  1983-02       Impact factor: 10.539

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