BACKGROUND: Early detection of cellular events is important to predict the outcome of the patients. This study was aimed to use (99m)Tc EC-annexin V to image tumor cells undergoing apoptosis. METHODS: In 10 patients with breast cancer, scintigraphic images and dosimetric estimates were obtained after administering (99m)Tc EC-annexin V. RESULTS: Nine of the 10 cases showed detectable (99m)Tc EC-annexin V uptake in tumor. Higher values of T/N ratios are associated with patient after treatment. CONCLUSIONS: Apoptosis can be quantified using (99m)Tc EC-annexin V.
BACKGROUND: Early detection of cellular events is important to predict the outcome of the patients. This study was aimed to use (99m)Tc EC-annexin V to image tumor cells undergoing apoptosis. METHODS: In 10 patients with breast cancer, scintigraphic images and dosimetric estimates were obtained after administering (99m)Tc EC-annexin V. RESULTS: Nine of the 10 cases showed detectable (99m)Tc EC-annexin V uptake in tumor. Higher values of T/N ratios are associated with patient after treatment. CONCLUSIONS: Apoptosis can be quantified using (99m)Tc EC-annexin V.
Authors: D J Yang; A Azhdarinia; P Wu; D F Yu; W Tansey; S K Kalimi; E E Kim; D A Podoloff Journal: Cancer Biother Radiopharm Date: 2001-02 Impact factor: 3.099
Authors: S Ilgan; D J Yang; T Higuchi; F Zareneyrizi; H Bayhan; D Yu; E E Kim; D A Podoloff Journal: Cancer Biother Radiopharm Date: 1998-12 Impact factor: 3.099
Authors: J A Wheeler; L C Stephens; C Tornos; P J Eifel; K K Ang; L Milas; P K Allen; R E Meyn Journal: Int J Radiat Oncol Biol Phys Date: 1995-07-30 Impact factor: 7.038
Authors: Tarik Z Belhocine; Francis G Blankenberg; Marina S Kartachova; Larry W Stitt; Jean-Luc Vanderheyden; Frank J P Hoebers; Christophe Van de Wiele Journal: Eur J Nucl Med Mol Imaging Date: 2015-08-16 Impact factor: 9.236
Authors: Donald J Johann; Jaime Rodriguez-Canales; Sumana Mukherjee; DaRue A Prieto; Jeffrey C Hanson; Michael Emmert-Buck; Josip Blonder Journal: J Proteome Res Date: 2009-05 Impact factor: 4.466