Literature DB >> 18305352

Cyslabdan, a new potentiator of imipenem activity against methicillin-resistant Staphylococcus aureus, produced by Streptomyces sp. K04-0144. I. Taxonomy, fermentation, isolation and structural elucidation.

Atsushi Fukumoto1, Yong-Pil Kim, Atsuko Matsumoto, Yoko Takahashi, Kazuro Shiomi, Hiroshi Tomoda, Satoshi Omura.   

Abstract

Cyslabdan, a new potentiator of imipenem activity against methicillin-resistant Staphylococcus aureus, was isolated from the culture broth of Streptomyces sp. K04-0144 by Diaion HP-20 and ODS column chromatographies and preparative HPLC. The structure of cyslabdan was elucidated by spectroscopic analyses including NMR. The compound has a labdane-type diterpene skeleton connecting with an N-acetylcysteine via thioether linkage.

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Year:  2008        PMID： 18305352     DOI： 10.1038/ja.2008.101

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  7 in total

Review 1.  Streptomycetes: Surrogate hosts for the genetic manipulation of biosynthetic gene clusters and production of natural products.

Authors:  Keshav K Nepal; Guojun Wang
Journal:  Biotechnol Adv       Date:  2018-10-09       Impact factor: 14.227

2.  Streptomyces lactacystinicus sp. nov. and Streptomyces cyslabdanicus sp. nov., producing lactacystin and cyslabdan, respectively.

Authors:  Akira Také; Atsuko Matsumoto; Satoshi Ōmura; Yōko Takahashi
Journal:  J Antibiot (Tokyo)       Date:  2014-12-10       Impact factor: 2.649

3.  Biosynthesis of mercapturic acid derivative of the labdane-type diterpene, cyslabdan that potentiates imipenem activity against methicillin-resistant Staphylococcus aureus: cyslabdan is generated by mycothiol-mediated xenobiotic detoxification.

Authors:  Haruo Ikeda; Kazuo Shin-Ya; Tohru Nagamitsu; Hiroshi Tomoda
Journal:  J Ind Microbiol Biotechnol       Date:  2015-10-27       Impact factor: 3.346

4.  The nonantibiotic small molecule cyslabdan enhances the potency of β-lactams against MRSA by inhibiting pentaglycine interpeptide bridge synthesis.

Authors:  Nobuhiro Koyama; Yuriko Tokura; Daniela Münch; Hans-Georg Sahl; Tanja Schneider; Yoshio Shibagaki; Haruo Ikeda; Hiroshi Tomoda
Journal:  PLoS One       Date:  2012-11-06       Impact factor: 3.240

Review 5.  Bacterial terpenome.

Authors:  Jeffrey D Rudolf; Tyler A Alsup; Baofu Xu; Zining Li
Journal:  Nat Prod Rep       Date:  2021-05-26       Impact factor: 15.111

Review 6.  Medicinal Plants and Their Bacterial Microbiota: A Review on Antimicrobial Compounds Production for Plant and Human Health.

Authors:  Lara Mitia Castronovo; Alberto Vassallo; Alessio Mengoni; Elisangela Miceli; Patrizia Bogani; Fabio Firenzuoli; Renato Fani; Valentina Maggini
Journal:  Pathogens       Date:  2021-01-22

Review 7.  Anti-infectious agents against MRSA.

Authors:  Nobuhiro Koyama; Junji Inokoshi; Hiroshi Tomoda
Journal:  Molecules       Date:  2012-12-24       Impact factor: 4.411
  7 in total

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