Literature DB >> 18304270

Chloroquine-resistance molecular markers (Pfcrt T76 and Pfmdr-1 Y86) and amodiaquine resistance in Burkina Faso.

Halidou Tinto1, Lougué Guekoun, Issaka Zongo, Robert Tinga Guiguemdé, Umberto D'Alessandro, Jean Bosco Ouédraogo.   

Abstract

We investigated the relationship between the two main molecular markers for chloroquine resistance (Pfcrt T76 and Pfmdr-1 Y86) and the clinical efficacy of amodiaquine in Burkina Faso. Before treatment, the prevalence of Pfcrt T76, Pfmdr-1 Y86 or both mutations in the same infection was significantly higher in patients who experienced a recrudescence than in those who successfully responded to the treatment. Therefore, these two molecular markers could be useful in monitoring amodiaquine resistance, particularly in countries where this drug is used in combination with artesunate as first- or second-line treatment.

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Year:  2008        PMID： 18304270     DOI： 10.1111/j.1365-3156.2007.01995.x

Source DB:  PubMed          Journal:  Trop Med Int Health        ISSN： 1360-2276            Impact factor:   2.622


  26 in total

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3.  In vivo selection of Plasmodium falciparum Pfcrt and Pfmdr1 variants by artemether-lumefantrine and dihydroartemisinin-piperaquine in Burkina Faso.

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Journal:  Malar J       Date:  2009-02-26       Impact factor: 2.979

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Journal:  Int J Mol Sci       Date:  2021-06-03       Impact factor: 5.923
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