Literature DB >> 18302330

Synthesis and characterization of stable fluorocarbon nanostructures as drug delivery vehicles for cytolytic peptides.

Neelesh R Soman1, Gregory M Lanza, John M Heuser, Paul H Schlesinger, Samuel A Wickline.   

Abstract

The therapeutic potential of cytolytic peptides is plagued by nonspecificity and enzymatic degradation. We report the first stable incorporation of melittin (a 26 amino acid amphipathic peptide) into an outer lipid monolayer of perfluorocarbon nanoparticles. Melittin binds avidly to the nanoparticles (dissociation constant approximately 3.27 nM) and retains its pore-forming activity after contact-mediated delivery to model bilayer membrane (liposomes) thereby demonstrating the effectiveness of perfluorocarbon nanoparticles as unique nanocarriers for cytolytic peptides.

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Year:  2008        PMID： 18302330      PMCID： PMC2710241          DOI： 10.1021/nl073290r

Source DB:  PubMed          Journal:  Nano Lett        ISSN： 1530-6984            Impact factor:   11.189


  31 in total

1.  BAX-dependent transport of cytochrome c reconstituted in pure liposomes.

Authors:  M Saito; S J Korsmeyer; P H Schlesinger
Journal:  Nat Cell Biol       Date:  2000-08       Impact factor: 28.824

2.  Reversible merger of membranes at the early stage of influenza hemagglutinin-mediated fusion.

Authors:  E Leikina; L V Chernomordik
Journal:  Mol Biol Cell       Date:  2000-07       Impact factor: 4.138

3.  Barrel-stave model or toroidal model? A case study on melittin pores.

Authors:  L Yang; T A Harroun; T M Weiss; L Ding; H W Huang
Journal:  Biophys J       Date:  2001-09       Impact factor: 4.033

Review 4.  Oxygen carriers ("blood substitutes")--raison d'etre, chemistry, and some physiology.

Authors:  J G Riess
Journal:  Chem Rev       Date:  2001-09       Impact factor: 60.622

5.  Anchor chain length alters the apparent mechanism of chloride channel function in SCMTR derivatives.

Authors:  Paul H Schlesinger; Natasha K Djedovic; Riccardo Ferdani; Jolanta Pajewska; Robert Pajewski; George W Gokel
Journal:  Chem Commun (Camb)       Date:  2003-02-07       Impact factor: 6.222

6.  The combined effects of antibacterial peptide cecropin A and anti-cancer agents on leukemia cells.

Authors:  Ling Hui; Keith Leung; Hueih Min Chen
Journal:  Anticancer Res       Date:  2002 Sep-Oct       Impact factor: 2.480

7.  The rate of lipid transfer during fusion depends on the structure of fluorescent lipid probes: a new chain-labeled lipid transfer probe pair.

Authors:  V S Malinin; M E Haque; B R Lentz
Journal:  Biochemistry       Date:  2001-07-27       Impact factor: 3.162

8.  Lipid-protein interactions in the membrane: studies with model peptides.

Authors:  S Mall; R P Sharma; J M East; A G Lee
Journal:  Faraday Discuss       Date:  1998       Impact factor: 4.008

9.  Exploring peptide membrane interaction using surface plasmon resonance: differentiation between pore formation versus membrane disruption by lytic peptides.

Authors:  Niv Papo; Yechiel Shai
Journal:  Biochemistry       Date:  2003-01-21       Impact factor: 3.162

10.  Lipid-protein interactions studied by introduction of a tryptophan residue: the mechanosensitive channel MscL.

Authors:  Andrew M Powl; J Malcolm East; Anthony G Lee
Journal:  Biochemistry       Date:  2003-12-09       Impact factor: 3.162
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  53 in total

1.  Lipid membrane editing with peptide cargo linkers in cells and synthetic nanostructures.

Authors:  Hua Pan; Jacob W Myerson; Olena Ivashyna; Neelesh R Soman; Jon N Marsh; Joshua L Hood; Gregory M Lanza; Paul H Schlesinger; Samuel A Wickline
Journal:  FASEB J       Date:  2010-03-24       Impact factor: 5.191

2.  Peptide-siRNA nanocomplexes targeting NF-κB subunit p65 suppress nascent experimental arthritis.

Authors:  Hui-fang Zhou; Huimin Yan; Hua Pan; Kirk K Hou; Antonina Akk; Luke E Springer; Ying Hu; J Stacy Allen; Samuel A Wickline; Christine T N Pham
Journal:  J Clin Invest       Date:  2014-08-26       Impact factor: 14.808

3.  Amphiphilic hyperbranched fluoropolymers as nanoscopic 19F magnetic resonance imaging agent assemblies.

Authors:  Wenjun Du; Andreas M Nyström; Lei Zhang; Kenya T Powell; Yali Li; Chong Cheng; Samuel A Wickline; Karen L Wooley
Journal:  Biomacromolecules       Date:  2008-09-17       Impact factor: 6.988

4.  Synthesis and characterization of perfluoro-tert-butyl semifluorinated amphiphilic polymers and their potential application in hydrophobic drug delivery.

Authors:  Sarah Decato; Troy Bemis; Eric Madsen; Sandro Mecozzi
Journal:  Polym Chem       Date:  2014-11-21       Impact factor: 5.582

Review 5.  Applications of RNA interference in the treatment of arthritis.

Authors:  Muhammad Farooq Rai; Hua Pan; Huimin Yan; Linda J Sandell; Christine T N Pham; Samuel A Wickline
Journal:  Transl Res       Date:  2019-07-10       Impact factor: 7.012

Review 6.  Peripheral Nerve Nanoimaging: Monitoring Treatment and Regeneration.

Authors:  Jelena M Janjic; Vijay S Gorantla
Journal:  AAPS J       Date:  2017-08-04       Impact factor: 4.009

7.  Postformulation peptide drug loading of nanostructures.

Authors:  Hua Pan; Jon N Marsh; Eric T Christenson; Neelesh R Soman; Olena Ivashyna; Gregory M Lanza; Paul H Schlesinger; Samuel A Wickline
Journal:  Methods Enzymol       Date:  2012       Impact factor: 1.600

Review 8.  Perfluorocarbon nanoemulsions for quantitative molecular imaging and targeted therapeutics.

Authors:  Megan M Kaneda; Shelton Caruthers; Gregory M Lanza; Samuel A Wickline
Journal:  Ann Biomed Eng       Date:  2009-01-30       Impact factor: 3.934

Review 9.  Polymeric micelles in anticancer therapy: targeting, imaging and triggered release.

Authors:  Chris Oerlemans; Wouter Bult; Mariska Bos; Gert Storm; J Frank W Nijsen; Wim E Hennink
Journal:  Pharm Res       Date:  2010-08-20       Impact factor: 4.200

10.  Bone-Induced Expression of Integrin β3 Enables Targeted Nanotherapy of Breast Cancer Metastases.

Authors:  Michael H Ross; Alison K Esser; Gregory C Fox; Anne H Schmieder; Xiaoxia Yang; Grace Hu; Dipanjan Pan; Xinming Su; Yalin Xu; Deborah V Novack; Thomas Walsh; Graham A Colditz; Gabriel H Lukaszewicz; Elizabeth Cordell; Joshua Novack; James A J Fitzpatrick; David L Waning; Khalid S Mohammad; Theresa A Guise; Gregory M Lanza; Katherine N Weilbaecher
Journal:  Cancer Res       Date:  2017-08-30       Impact factor: 12.701
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