PURPOSE: To report a case illustrating the value of pattern VEP and pattern ERG (PERG) in monitoring optic nerve gliomata (OG). CASE REPORT: A 15-year-old girl presented with a 3-year history of frontal headaches and a 5-month history of blurred vision in the right eye. MRI scanning revealed a thickened, right optic nerve extending to the cranial opening of the optic canal, consistent with an optic nerve glioma. Pattern VEP showed a mildly delayed major positive component consistent with optic nerve dysfunction. The PERG N95:P50 ratio was subnormal in keeping with retinal ganglion cell involvement. Visual acuity decreased over the following 2 years and repeat VEP objectively demonstrated marked deterioration in optic nerve function despite neuroradiology showing no significant change in the tumour. CONCLUSIONS: Pattern VEPs and pattern ERGs can provide early objective evidence of optic nerve/retinal ganglion cell dysfunction in optic nerve gliomata. Serial recordings can objectively demonstrate worsening function in the absence of significant neuroradiological change.
PURPOSE: To report a case illustrating the value of pattern VEP and pattern ERG (PERG) in monitoring optic nerve gliomata (OG). CASE REPORT: A 15-year-old girl presented with a 3-year history of frontal headaches and a 5-month history of blurred vision in the right eye. MRI scanning revealed a thickened, right optic nerve extending to the cranial opening of the optic canal, consistent with an optic nerve glioma. Pattern VEP showed a mildly delayed major positive component consistent with optic nerve dysfunction. The PERG N95:P50 ratio was subnormal in keeping with retinal ganglion cell involvement. Visual acuity decreased over the following 2 years and repeat VEP objectively demonstrated marked deterioration in optic nerve function despite neuroradiology showing no significant change in the tumour. CONCLUSIONS: Pattern VEPs and pattern ERGs can provide early objective evidence of optic nerve/retinal ganglion cell dysfunction in optic nerve gliomata. Serial recordings can objectively demonstrate worsening function in the absence of significant neuroradiological change.
Authors: Anthony G Robson; Ahmed El-Amir; Claire Bailey; Catherine A Egan; Frederick W Fitzke; Andrew R Webster; Alan C Bird; Graham E Holder Journal: Invest Ophthalmol Vis Sci Date: 2003-08 Impact factor: 4.799
Authors: M Vanasse; J Y Gabet; J De Léan; F Mauguière; P Sabouraud; J P Bouchard; J Mathieu Journal: Electroencephalogr Clin Neurophysiol Suppl Date: 1990
Authors: L N Rossi; G Pastorino; G Scotti; M Gazocchi; M M Maninetti; C Zanolini; A Chiodi Journal: Childs Nerv Syst Date: 1994-09 Impact factor: 1.475