BACKGROUND: We investigated the effects of length of exposure to tobacco smoke on the cardiac remodeling process induced by exposure to cigarette smoke in rats. MATERIAL/ METHODS: Rats were separated into 4 groups: nonsmoking (NS)2 (n=25; control animals not exposed to tobacco smoke for 2 months), smoking (S)2 (n=22; rats exposed to smoke from 40 cigarettes/d for 2 months), NS6 (n=18; control animals not exposed to tobacco smoke for 6 months), and S6 (n=25; rats exposed to smoke from 40 cigarettes/d for 6 months). All animals underwent echocardiographic, isolated heart, and morphometric studies. Data were analyzed with a 2-way analysis of variance. RESULTS: No interaction among the variables was found; this suggests that length of exposure to tobacco smoke did not influence the effects of exposure to smoke. Values for left ventricular diastolic diameter/body weight and left atrium/body weight were higher (p=0.023 and p=0.001, respectively) in smoking (S2 and S6) than in nonsmoking animals (NS2 and NS6). Left ventricular mass index was higher (p=0.048) in smoking than in nonsmoking animals. In the isovolumetrically beating ventricle, peak systolic pressure was higher (p=0.034) in smoking than in nonsmoking animals. Significantly higher values were found for left ventricular weight (p=0.017) and right ventricular weight (p=0.001) adjusted for body weight in smoking as opposed to nonsmoking animals. Systolic pressure was higher (p=0.001) in smoking (128+/-14 mm Hg) than in nonsmoking animals (112+/-11 mm Hg). CONCLUSIONS: Length of exposure to cigarette smoke did not influence cardiac remodeling caused by exposure to smoke in rats.
BACKGROUND: We investigated the effects of length of exposure to tobacco smoke on the cardiac remodeling process induced by exposure to cigarette smoke in rats. MATERIAL/ METHODS:Rats were separated into 4 groups: nonsmoking (NS)2 (n=25; control animals not exposed to tobacco smoke for 2 months), smoking (S)2 (n=22; rats exposed to smoke from 40 cigarettes/d for 2 months), NS6 (n=18; control animals not exposed to tobacco smoke for 6 months), and S6 (n=25; rats exposed to smoke from 40 cigarettes/d for 6 months). All animals underwent echocardiographic, isolated heart, and morphometric studies. Data were analyzed with a 2-way analysis of variance. RESULTS: No interaction among the variables was found; this suggests that length of exposure to tobacco smoke did not influence the effects of exposure to smoke. Values for left ventricular diastolic diameter/body weight and left atrium/body weight were higher (p=0.023 and p=0.001, respectively) in smoking (S2 and S6) than in nonsmoking animals (NS2 and NS6). Left ventricular mass index was higher (p=0.048) in smoking than in nonsmoking animals. In the isovolumetrically beating ventricle, peak systolic pressure was higher (p=0.034) in smoking than in nonsmoking animals. Significantly higher values were found for left ventricular weight (p=0.017) and right ventricular weight (p=0.001) adjusted for body weight in smoking as opposed to nonsmoking animals. Systolic pressure was higher (p=0.001) in smoking (128+/-14 mm Hg) than in nonsmoking animals (112+/-11 mm Hg). CONCLUSIONS: Length of exposure to cigarette smoke did not influence cardiac remodeling caused by exposure to smoke in rats.
Authors: M A Hassan Talukder; Wesley M Johnson; Saradhadevi Varadharaj; Jiarui Lian; Patrick N Kearns; Mohamed A El-Mahdy; Xiaoping Liu; Jay L Zweier Journal: Am J Physiol Heart Circ Physiol Date: 2010-11-05 Impact factor: 4.733
Authors: Priscila P Santos; Fernando Oliveira; Vanessa C M P Ferreira; Bertha F Polegato; Meliza G Roscani; Ana Angelica Fernandes; Pamela Modesto; Bruna P M Rafacho; Silmeia G Zanati; Annarita Di Lorenzo; Luiz S Matsubara; Sergio A R Paiva; Leonardo A M Zornoff; Marcos F Minicucci; Paula S Azevedo Journal: PLoS One Date: 2014-12-02 Impact factor: 3.240
Authors: Daniella R Duarte; Marcos F Minicucci; Paula S Azevedo; Beatriz B Matsubara; Luiz S Matsubara; Ethel L Novelli; Sergio A R Paiva; Leonardo A M Zornoff Journal: Clinics (Sao Paulo) Date: 2009 Impact factor: 2.365