BACKGROUND: Geographical variation and temporal trends in the incidence of esophageal and gastric cancers vary according to both tumour morphology and organ subsite. Both diseases are among the deadliest forms of cancer. The incidence and survival rates for gastric and esophageal carcinoma in British Columbia (BC) between 1990 and 1999 are described. METHODS: Incidence data for the period 1990 to 1999 were obtained from the BC Cancer Registry. Age-adjusted incidence and survival rates were computed by anatomical subsite, histological type and sex. All rates were standardized to the 1996 Canadian population. The estimated annual percentage change (EAPC) was used to measure incidence changes over time. Kaplan-Meier curves were used to show survival rates, and log-rank tests were used to test for differences in the curves among various groups. RESULTS: Between 1990 and 1999, 1741 esophageal cancer cases and 3431 gastric cancer cases were registered in BC. There was an increase in the incidence of adenocarcinoma of the esophagus over time (EAPC=9.6%) among men, and of gastric cardia cancer among both women (EAPC=9.2%) and men (EAPC=3.8%). Patients with proximal gastric (cardia) cancer had significantly better survival rates than patients with cancer in the lower one-third of the esophagus. Among gastric cancers, patients with distal tumours had a significantly better survival rate than patients with proximal tumours. DISCUSSION: The incidences of proximal gastric cancer and esophageal adenocarcinoma are increasing, and their survival patterns are different. Examining these cancers together may elucidate new etiological and prognostic factors.
BACKGROUND: Geographical variation and temporal trends in the incidence of esophageal and gastric cancers vary according to both tumour morphology and organ subsite. Both diseases are among the deadliest forms of cancer. The incidence and survival rates for gastric and esophageal carcinoma in British Columbia (BC) between 1990 and 1999 are described. METHODS: Incidence data for the period 1990 to 1999 were obtained from the BC Cancer Registry. Age-adjusted incidence and survival rates were computed by anatomical subsite, histological type and sex. All rates were standardized to the 1996 Canadian population. The estimated annual percentage change (EAPC) was used to measure incidence changes over time. Kaplan-Meier curves were used to show survival rates, and log-rank tests were used to test for differences in the curves among various groups. RESULTS: Between 1990 and 1999, 1741 esophageal cancer cases and 3431 gastric cancer cases were registered in BC. There was an increase in the incidence of adenocarcinoma of the esophagus over time (EAPC=9.6%) among men, and of gastric cardia cancer among both women (EAPC=9.2%) and men (EAPC=3.8%). Patients with proximal gastric (cardia) cancer had significantly better survival rates than patients with cancer in the lower one-third of the esophagus. Among gastric cancers, patients with distal tumours had a significantly better survival rate than patients with proximal tumours. DISCUSSION: The incidences of proximal gastric cancer and esophageal adenocarcinoma are increasing, and their survival patterns are different. Examining these cancers together may elucidate new etiological and prognostic factors.
Authors: Carlos A González; Guillem Pera; Antonio Agudo; Domenico Palli; Vittorio Krogh; Paolo Vineis; Rosario Tumino; Salvatore Panico; Göran Berglund; Henrik Simán; Olof Nyrén; Asa Agren; Carmen Martinez; Miren Dorronsoro; Aurelio Barricarte; María J Tormo; Jose R Quiros; Naomi Allen; Sheila Bingham; Nicholas Day; Antony Miller; Gabriele Nagel; Heiner Boeing; Kim Overvad; Anne Tjonneland; H Bas Bueno-De-Mesquita; Hendriek C Boshuizen; Petra Peeters; Mattijs Numans; François Clavel-Chapelon; Ishaki Helen; Emmanuel Agapitos; Eiliv Lund; Michael Fahey; Rodolfo Saracci; Rudolf Kaaks; Elio Riboli Journal: Int J Cancer Date: 2003-11-20 Impact factor: 7.396
Authors: Kfir Ben-David; George A Sarosi; Juan C Cendan; Drew Howard; Georgios Rossidis; Steven N Hochwald Journal: Surg Endosc Date: 2011-07-27 Impact factor: 4.584
Authors: Michael C Otterstatter; James D Brierley; Prithwish De; Larry F Ellison; Maureen Macintyre; Loraine D Marrett; Robert Semenciw; Hannah K Weir Journal: Can J Gastroenterol Date: 2012-10 Impact factor: 3.522
Authors: Morteza Bashash; T Greg Hislop; Amil M Shah; Nhu Le; Angela Brooks-Wilson; Chris D Bajdik Journal: BMC Cancer Date: 2011-05-09 Impact factor: 4.430