Babak Rajabi1, Javier C Corral, Nawar Hakim, Zuber D Mulla. 1. Department of Internal Medicine, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, TX, USA. brajabi@medicine.nevada.edu
Abstract
BACKGROUND: We aimed to evaluate the clinicopathological and demographic characteristics of gastric adenocarcinoma in Hispanics and compare these trends with those found in non-Hispanic Whites in Texas. METHODS: Records of patients with gastric adenocarcinoma found in the Texas Cancer Registry from 1995 to 2006 were reviewed. Four ethnic-geographic groups were formed: Hispanics residing in El Paso County (a county on the Texas-Mexico border), White non-Hispanics in El Paso County, Hispanics from the remaining counties of Texas combined, and White non-Hispanics from the remaining counties of Texas combined. Adjusted prevalence ratios (PRs) for the outcome of late stage at diagnosis were calculated. RESULTS: Of 9949 patients, 561 patients were El Paso County residents, of whom 83% were Hispanics. Among the four ethnic-geographic groups, the age-adjusted incidence was the highest in Hispanics in El Paso County (15.5 cases/100000). Tumor pathobiology varied by ethnicity. White non-Hispanics were more likely than Hispanics to have a proximal tumor and less likely to have a poorly differentiated or undifferentiated tumor. In El Paso County, patients in each of the eight age groups under 75 years compared to patients aged ≥85 years were significantly more likely to be at late stage (adjusted PRs 1.44-1.71). CONCLUSION: The incidence of gastric adenocarcinoma is higher in Hispanics than in Whites in both El Paso County and the remaining portion of Texas. Hispanics have a higher grade of gastric adenocarcinoma. The prevalence of late stage at the time of diagnosis is higher in younger patients than in older patients.
BACKGROUND: We aimed to evaluate the clinicopathological and demographic characteristics of gastric adenocarcinoma in Hispanics and compare these trends with those found in non-Hispanic Whites in Texas. METHODS: Records of patients with gastric adenocarcinoma found in the Texas Cancer Registry from 1995 to 2006 were reviewed. Four ethnic-geographic groups were formed: Hispanics residing in El Paso County (a county on the Texas-Mexico border), White non-Hispanics in El Paso County, Hispanics from the remaining counties of Texas combined, and White non-Hispanics from the remaining counties of Texas combined. Adjusted prevalence ratios (PRs) for the outcome of late stage at diagnosis were calculated. RESULTS: Of 9949 patients, 561 patients were El Paso County residents, of whom 83% were Hispanics. Among the four ethnic-geographic groups, the age-adjusted incidence was the highest in Hispanics in El Paso County (15.5 cases/100000). Tumor pathobiology varied by ethnicity. White non-Hispanics were more likely than Hispanics to have a proximal tumor and less likely to have a poorly differentiated or undifferentiated tumor. In El Paso County, patients in each of the eight age groups under 75 years compared to patients aged ≥85 years were significantly more likely to be at late stage (adjusted PRs 1.44-1.71). CONCLUSION: The incidence of gastric adenocarcinoma is higher in Hispanics than in Whites in both El Paso County and the remaining portion of Texas. Hispanics have a higher grade of gastric adenocarcinoma. The prevalence of late stage at the time of diagnosis is higher in younger patients than in older patients.
Authors: James C Yao; Jennifer F Tseng; Samidha Worah; Kenneth R Hess; Paul F Mansfield; Christopher H Crane; Isac I Schnirer; Satish Reddy; Silvia S Chiang; Azmeena Najam; Christina Yu; Geoffrey G Giacco; Keping Xie; Tsung-Teh Wu; Barry W Feig; Peter W T Pisters; Jaffer A Ajani Journal: J Clin Oncol Date: 2005-05-01 Impact factor: 44.544
Authors: Ahmedin Jemal; Taylor Murray; Elizabeth Ward; Alicia Samuels; Ram C Tiwari; Asma Ghafoor; Eric J Feuer; Michael J Thun Journal: CA Cancer J Clin Date: 2005 Jan-Feb Impact factor: 508.702
Authors: P K Dhillon; D C Farrow; T L Vaughan; W H Chow; H A Risch; M D Gammon; S T Mayne; J L Stanford; J B Schoenberg; H Ahsan; R Dubrow; A B West; H Rotterdam; W J Blot; J F Fraumeni Journal: Int J Cancer Date: 2001-07-01 Impact factor: 7.396
Authors: W H Chow; W J Blot; T L Vaughan; H A Risch; M D Gammon; J L Stanford; R Dubrow; J B Schoenberg; S T Mayne; D C Farrow; H Ahsan; A B West; H Rotterdam; S Niwa; J F Fraumeni Journal: J Natl Cancer Inst Date: 1998-01-21 Impact factor: 13.506
Authors: Juan E Corral; Juan J Delgado Hurtado; Ricardo L Domínguez; Marisabel Valdez de Cuéllar; Carlos Balmore Cruz; Douglas R Morgan Journal: J Gastrointest Cancer Date: 2015-03
Authors: Liang Ji; Matthew J Selleck; John W Morgan; Jane Xu; Blake D Babcock; David Shavlik; Nathan R Wall; William H Langridge; Sharon S Lum; Carlos A Garberoglio; Mark E Reeves; Naveenraj Solomon; Jukes P Namm; Maheswari Senthil Journal: Ann Surg Oncol Date: 2019-07-25 Impact factor: 5.344
Authors: Narjust Duma; Larysa J Sanchez; Yulanka S Castro; Andrew A Jennis; Donald A McCain; Martin E Gutierrez; Zubin M Bamboat Journal: Ann Gastroenterol Date: 2016-04-07