OBJECTIVE: This study assessed the effect of smoking crack cocaine on the nuclear area (NA), the cytoplasmic area (CA), and the nucleus-to-cytoplasm area ratio (NA/CA) of oral squamous epithelial cells. STUDY DESIGN: Oral smears were collected from clinically normal-appearing mucosa by liquid-based exfoliative cytology of 40 individuals (20 crack users and 20 nonusers) and analyzed for quantitative techniques using an image analysis system. RESULTS: Mean values of NA for experimental and control groups were, respectively, 49.85 microm(2) and 62.68 microm(2) (P < .01). CA showed the following mean values: 1820.9 microm(2) (experimental) and 1780.8 microm(2) (control). NA/CA for the experimental group was 0.03; the control group was 0.04 (P < .01). CONCLUSION: This study revealed that crack cocaine was able to induce significant changes on the oral epithelial cells. Since this illicit drug is normally used in association with other risk factors for oral cancer (tobacco and alcohol), crack cocaine abusers should have frequent preventive oral exams.
OBJECTIVE: This study assessed the effect of smoking crack cocaine on the nuclear area (NA), the cytoplasmic area (CA), and the nucleus-to-cytoplasm area ratio (NA/CA) of oral squamous epithelial cells. STUDY DESIGN: Oral smears were collected from clinically normal-appearing mucosa by liquid-based exfoliative cytology of 40 individuals (20 crack users and 20 nonusers) and analyzed for quantitative techniques using an image analysis system. RESULTS: Mean values of NA for experimental and control groups were, respectively, 49.85 microm(2) and 62.68 microm(2) (P < .01). CA showed the following mean values: 1820.9 microm(2) (experimental) and 1780.8 microm(2) (control). NA/CA for the experimental group was 0.03; the control group was 0.04 (P < .01). CONCLUSION: This study revealed that crack cocaine was able to induce significant changes on the oral epithelial cells. Since this illicit drug is normally used in association with other risk factors for oral cancer (tobacco and alcohol), crack cocaine abusers should have frequent preventive oral exams.
Authors: Magna Carvalho de M Thiele; Joslei Carlos Bohn; Cassiano Lima Chaiben; Ana Maria Trindade Grégio; Maria Ângela Naval Machado; Antonio Adilson Soares de Lima Journal: Iran Biomed J Date: 2013-04
Authors: César Antonio Araújo Melo; Hanna Rabech Garcia Guimarães; Raphael Crhistian Fernandes Medeiros; Georgia Costa de Araújo Souza; Patrícia Bittencourt Dutra Dos Santos; Ana Clara Soares Paiva Tôrres Journal: Braz J Otorhinolaryngol Date: 2021-05-14